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Gene Review:

dusp1 - dual specificity phosphatase 1

Xenopus (Silurana) tropicalis

Synonyms: XCL100, cl100, hvh1, mkp-1, mkp1, ...

Izumi, T. et al., Qian, Y.W. et al., Yang, J. et al., Kumagai, A. et al.

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High impact information on dusp1

Upon treatment with progesterone, these sites are dephosphorylated by the dual specificity phosphatase, Cdc25, leading to Cdc2-cyclin B1 activation [1].
Entry into mitosis depends upon activation of the dual-specificity phosphatase Cdc25C, which dephosphorylates and activates the cyclin B-Cdc2 complex [2].
Cdc25, the dual-specificity phosphatase that dephosphorylates the Cdc2-cyclin B complex at mitosis, is highly regulated during the cell cycle [3].
The M-phase inducer, Cdc25C, is a dual-specificity phosphatase that directly phosphorylates and activates the cyclin B/Cdc2 kinase complex, leading to initiation of mitosis [4].

References

Maintenance of G2 arrest in the Xenopus oocyte: a role for 14-3-3-mediated inhibition of Cdc25 nuclear import. Yang, J., Winkler, K., Yoshida, M., Kornbluth, S. EMBO J. (1999) [Pubmed]
Activated polo-like kinase Plx1 is required at multiple points during mitosis in Xenopus laevis. Qian, Y.W., Erikson, E., Li, C., Maller, J.L. Mol. Cell. Biol. (1998) [Pubmed]
14-3-3 proteins act as negative regulators of the mitotic inducer Cdc25 in Xenopus egg extracts. Kumagai, A., Yakowec, P.S., Dunphy, W.G. Mol. Biol. Cell (1998) [Pubmed]
Phosphorylation and activation of the Xenopus Cdc25 phosphatase in the absence of Cdc2 and Cdk2 kinase activity. Izumi, T., Maller, J.L. Mol. Biol. Cell (1995) [Pubmed]

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