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Gene Review

DUSP1  -  dual specificity phosphatase 1

Bos taurus

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High impact information on MKP-1

  • MKP1 phosphorylated threonine residues and MPK2 serine residues of casein [1].
  • These results indicate that beraprost inhibits the proliferation of mesangial cells and one of the mechanisms might be cAMP-dependent induction of MKP-1 [2].


  1. Purification and characterization of two protein kinases from bovine heart mitochondrial membrane. Kitagawa, Y., Racker, E. J. Biol. Chem. (1982) [Pubmed]
  2. Beraprost sodium, an analogue of prostacyclin, induces the expression of mitogen-activated protein kinase phosphatase and inhibits the proliferation of cultured mesangial cells. Togawa, M., Haneda, M., Araki, S., Sugimoto, T., Isono, M., Hidaka, H., Yasuda, H., Kashiwagi, A., Kikkawa, R. Eur. J. Pharmacol. (1997) [Pubmed]
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