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Gene Review:

Acam - Androcam

Drosophila melanogaster

Synonyms: ACaM, And, CG17769, Calmodulin-related protein 97A, Camr97A, ...

Martin, S.R. et al., Pavlik, P. et al., Frank, D.J. et al.

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High impact information on And

Androcam is a tissue-specific light chain for myosin VI in the Drosophila testis [1].
Androcam is a Drosophila melanogaster calmodulin-related protein that functions specifically in the testis [2].
The two EF hands of the C-domain of androcam bind calcium cooperatively with 40-fold higher average affinity than the corresponding calmodulin sites [3].
Molecular modeling supports the deduction that there are significant conformational differences in the N-domain of androcam compared to calmodulin, and that these could affect the surface, conferring a different specificity on androcam in target interactions related to testis-specific calcium signaling functions [3].

Other interactions of And

From the sequence differences and the altered calcium-binding properties it is likely that androcam differs from calmodulin in the conformation of residues in the second calcium-binding loop [3].

References

Androcam is a tissue-specific light chain for myosin VI in the Drosophila testis. Frank, D.J., Martin, S.R., Gruender, B.N., Lee, Y.S., Simonette, R.A., Bayley, P.M., Miller, K.G., Beckingham, K.M. J. Biol. Chem. (2006) [Pubmed]
A dicistronic gene pair within a cluster of "EF-hand" protein genes in the genomes of Drosophila species. Pavlik, P., Konduri, V., Massa, E., Simonette, R., Beckingham, K.M. Genomics (2006) [Pubmed]
Conformational and metal-binding properties of androcam, a testis-specific, calmodulin-related protein from Drosophila. Martin, S.R., Lu, A.Q., Xiao, J., Kleinjung, J., Beckingham, K., Bayley, P.M. Protein Sci. (1999) [Pubmed]

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