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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HTR2C  -  5-hydroxytryptamine (serotonin) receptor...

Canis lupus familiaris

Synonyms: 5-HT-2C, 5-HTR2C
 
 
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Disease relevance of HTR2C

  • 5-HT2C agonists have shown efficacy in limiting food consumption and thus may serve as an important drug class in combating obesity [1].
 

High impact information on HTR2C

  • Prior close intra-arterial infusions of 5-HT1A/5-HT1B, 5-HT2A, 5-HT2C, and 5-HT4 receptor antagonists had no significant effect on the contractile response to 5-HT [2].
  • We conclude that in the conscious state, 5-HT acts on 5-HT2A and 5-HT2C receptors located on postsynaptic cholinergic neurons in the canine jejunum to stimulate phasic contractions and phase III activity [3].

References

  1. The design and synthesis of a tricyclic single-nitrogen scaffold that serves as a 5-HT2C receptor agonist. Huck, B.R., Llamas, L., Robarge, M.J., Dent, T.C., Song, J., Hodnick, W.F., Crumrine, C., Stricker-Krongrad, A., Harrington, J., Brunden, K.R., Bennani, Y.L. Bioorg. Med. Chem. Lett. (2006) [Pubmed]
  2. 5-HT-induced colonic contractions: enteric locus of action and receptor subtypes. Graf, S., Sarna, S.K. Am. J. Physiol. (1997) [Pubmed]
  3. 5-HT-induced jejunal motor activity: enteric locus of action and receptor subtypes. Graf, S., Sarna, S.K. Am. J. Physiol. (1996) [Pubmed]
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