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Disease relevance of Obesity


Psychiatry related information on Obesity


High impact information on Obesity

  • Insulin resistance plays a key role in the pathogenesis of several human diseases, including diabetes, obesity, hypertension, and cardiovascular diseases [12].
  • Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity [13].
  • Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes [14].
  • In an era marked by the increasing prevalence of obesity, diabetes, and cardiovascular disease, the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma) has emerged as a transcriptional regulator of metabolism whose activity can be modulated by direct binding of small molecules [15].
  • Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits [16].

Chemical compound and disease context of Obesity

  • To investigate whether abnormal insulin oscillations are an early feature of diabetes, we studied 10 minimally glucose-intolerant first-degree relatives of patients with non-insulin-dependent diabetes and 10 controls matched for age and obesity [17].
  • Bile cholesterol saturation correlated with obesity (r = 0.41; P less than 0.001) and urinary estrogen excretion (r = 0.44; P less than 0.001) [18].
  • Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat [19].
  • The increases may be explained by dysregulation of 11 beta-hydroxysteroid dehydrogenase causing increased oxidation of cortisol to cortisone, which cannot be accounted for by obesity [20].
  • We studied the relation in Pima Indians between obesity in children and diabetes during pregnancy in their mothers [21].
  • The clinically and statistically significant weight reduction caused by sibutramine in this short-term study indicates that treatment of hypothalamic and syndromal obesity with this drug may be beneficial [22].
  • We further defined where in the body cilia are required for normal energy homeostasis by disrupting cilia on neurons throughout the central nervous system and on pro-opiomelanocortin-expressing cells in the hypothalamus, both of which resulted in obesity [23].
  • Drugs that inhibit GOAT might be able to prevent diet-induced obesity and might be an effective therapy for type-2 diabetes, increasing insulin secretion and enhancing peripheral insulin sensitivity [24].

Biological context of Obesity


Anatomical context of Obesity


Gene context of Obesity


Analytical, diagnostic and therapeutic context of Obesity


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