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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

dom  -  domino

Drosophila melanogaster

Synonyms: 27/4, CG9696, DOM, Dmel\CG9696, Dom, ...
 
 
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High impact information on dom

  • The Domino proteins are present in large complexes in embryo extracts, and one isoform binds to a number of discrete sites on larval polytene chromosomes [1].
  • These features are shared with three other components of TIP60 complexes, namely Enhancer of Polycomb, Domino, and dMRG15 [2].
  • The iswi mutant germline stem cells are lost rapidly because of defects in responding to bone morphogenetic protein niche signals and in repressing differentiation, whereas the dom mutant somatic stem cells are lost because of defective self-renewal [3].

References

  1. The domino gene of Drosophila encodes novel members of the SWI2/SNF2 family of DNA-dependent ATPases, which contribute to the silencing of homeotic genes. Ruhf, M.L., Braun, A., Papoulas, O., Tamkun, J.W., Randsholt, N., Meister, M. Development (2001) [Pubmed]
  2. Drosophila Reptin and Other TIP60 Complex Components Promote Generation of Silent Chromatin. Qi, D., Jin, H., Lilja, T., Mannervik, M. Genetics (2006) [Pubmed]
  3. Stem cell self-renewal controlled by chromatin remodeling factors. Xi, R., Xie, T. Science (2005) [Pubmed]
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