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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MYD88  -  myeloid differentiation primary response 88

Homo sapiens

Synonyms: Myeloid differentiation primary response protein MyD88
 
 
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High impact information on MYD88

  • In this study, we found that the numbers of CD8alphaalpha TCRalphabeta and TCRgammadelta intestinal intraepithelial lymphocytes (i-IELs) were significantly decreased in MyD88-deficient (-/-) mice [1].
  • The smallest region homozygously deleted in 3p21.3T was flanked by D3S1298 and NL1-024 (D3S4285), excluding DLEC1 and MYD88 as candidate TSGs involved in cervical carcinogenesis [2].
  • This was paralleled by enhanced transcript levels of TLR4 and Myd88 in patients with UA and AMI (P<0.0001) and increased expression of IL-12 (UA 35.5+/-7.8, AMI 31.8+/-7.7 versus SA 2.2+/-0.5, controls 2.1+/-0.3 pg/mL; P<0.0002) and B7-1 (UA 27.3+/-14.4, AMI 22.6+/-11.1 versus SA 3.4+/-2.5, controls 2.4+/-2.3%; P<0.0001) [3].
  • The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades [4].
 

Analytical, diagnostic and therapeutic context of MYD88

  • A chemically modified antisense oligonucleotide (ASO) that alters the splicing ratio of MyD88 to MyD88(S) in both cell culture and in animals has been identified [5].

References

  1. MyD88-Dependent Signaling for IL-15 Production Plays an Important Role in Maintenance of CD8{alpha}{alpha} TCR{alpha}beta and TCR{gamma}{delta} Intestinal Intraepithelial Lymphocytes. Yu, Q., Tang, C., Xun, S., Yajima, T., Takeda, K., Yoshikai, Y. J. Immunol. (2006) [Pubmed]
  2. Deletion mapping using quantitative real-time PCR identifies two distinct 3p21.3 regions affected in most cervical carcinomas. Senchenko, V., Liu, J., Braga, E., Mazurenko, N., Loginov, W., Seryogin, Y., Bazov, I., Protopopov, A., Kisseljov, F.L., Kashuba, V., Lerman, M.I., Klein, G., Zabarovsky, E.R. Oncogene (2003) [Pubmed]
  3. Expansion of circulating Toll-like receptor 4-positive monocytes in patients with acute coronary syndrome. Methe, H., Kim, J.O., Kofler, S., Weis, M., Nabauer, M., Koglin, J. Circulation (2005) [Pubmed]
  4. The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades. Björkbacka, H., Fitzgerald, K.A., Huet, F., Li, X., Gregory, J.A., Lee, M.A., Ordija, C.M., Dowley, N.E., Golenbock, D.T., Freeman, M.W. Physiol. Genomics (2004) [Pubmed]
  5. Modification of MyD88 mRNA splicing and inhibition of IL-1beta signaling in cell culture and in mice with a 2'-O-methoxyethyl-modified oligonucleotide. Vickers, T.A., Zhang, H., Graham, M.J., Lemonidis, K.M., Zhao, C., Dean, N.M. J. Immunol. (2006) [Pubmed]
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