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Gene Review

APC  -  adenomatous polyposis coli

Pan troglodytes

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High impact information on APC

  • More importantly, they show that the s.c. route of injection delivers these APC to sites of T cell activation, a prerequisite for the generation of an effective immune response [1].
  • The injected cells interdigitate with T cells in the parafollicular and paracortical zones and retain high level expression of CD86, CD40, and MHC class II molecules, reflecting a phenotype of potent APC [1].


  1. In vivo migration of dendritic cells differentiated in vitro: a chimpanzee model. Barratt-Boyes, S.M., Watkins, S.C., Finn, O.J. J. Immunol. (1997) [Pubmed]
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