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Gene Review

apc  -  adenomatous polyposis coli

Danio rerio

Synonyms: SO:0000704, cb965, im:7150932, im:7152872
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High impact information on apc

  • In contrast, treatment of apc mutants with all-trans retinoic acid rescued retinal differentiation defects but had no apparent effect on the lens [1].
  • These observations establish apc-mutant zebrafish as a bona fide model for the study of digestive tract cancer [2].


  1. Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development. Nadauld, L.D., Chidester, S., Shelton, D.N., Rai, K., Broadbent, T., Sandoval, I.T., Peterson, P.W., Manos, E.J., Ireland, C.M., Yost, H.J., Jones, D.A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Adenomatous polyposis coli-deficient zebrafish are susceptible to digestive tract neoplasia. Haramis, A.P., Hurlstone, A., van der Velden, Y., Begthel, H., van den Born, M., Offerhaus, G.J., Clevers, H.C. EMBO Rep. (2006) [Pubmed]
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