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Gene Review

Apc  -  adenomatous polyposis coli

Rattus norvegicus

Synonyms: Adenomatous polyposis coli protein, Protein APC
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Disease relevance of Apc


Psychiatry related information on Apc


High impact information on Apc


Chemical compound and disease context of Apc


Biological context of Apc


Anatomical context of Apc

  • These findings suggest a role for the beta-catenin-APC complex in the proliferation and migration of vascular endothelial cells during neovascularization of the infarct area [11].
  • Between 12 and 24 h after plating, APC concentrated at the growth cone and in the distal portion of the longest process, which was growing very rapidly [12].
  • This subcellular distribution of APC was dependent on the organization of microtubules, but not actin filaments [12].
  • Activation of the Par6-PKCzeta complex by Cdc42 at the leading edge of migrating cells promotes both the localized association of APC with microtubule plus ends and the assembly of Dlg-containing puncta in the plasma membrane [13].
  • Biochemical analysis and total internal reflection fluorescence microscopy reveal that the subsequent physical interaction between APC and Dlg1 is required for polarization of the microtubule cytoskeleton [13].

Associations of Apc with chemical compounds


Physical interactions of Apc


Other interactions of Apc

  • In an attempt to determine the genetic factors implicated in the susceptibility to formation of ACFs, a possible involvement of the adenomatous polyposis gene (Apc) and its modifier secretory phospholipase A2 (Pla2g2a) was analyzed [19].

Analytical, diagnostic and therapeutic context of Apc


  1. Carcinogenicity of aminophenylnorharman, a possible novel endogenous mutagen, formed from norharman and aniline, in F344 rats. Kawamori, T., Totsuka, Y., Uchiya, N., Kitamura, T., Shibata, H., Sugimura, T., Wakabayashi, K. Carcinogenesis (2004) [Pubmed]
  2. Cell density and phosphorylation control the subcellular localization of adenomatous polyposis coli protein. Zhang, F., White, R.L., Neufeld, K.L. Mol. Cell. Biol. (2001) [Pubmed]
  3. Proteomic analysis of intestinal epithelial cells expressing stabilized beta-catenin. Seike, M., Kondo, T., Mori, Y., Gemma, A., Kudoh, S., Sakamoto, M., Yamada, T., Hirohashi, S. Cancer Res. (2003) [Pubmed]
  4. Mutations of adenomatous polyposis coli and beta-catenin genes during progression of lung tumors induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Tsujiuchi, T., Tsutsumi, M., Sasaki, Y., Murata, N., Konishi, Y. Cancer Res. (2000) [Pubmed]
  5. Adenomatous polyposis coli protein is expressed in alternate stages of the ameloblast life cycle. Wang, M., Dobeck, J.M., Sorkin, B.C., Skobe, Z. J. Dent. Res. (1998) [Pubmed]
  6. Increase of adenomatous polyposis coli immunoreactivity is a marker of reactive astrocytes in Alzheimer's disease and in other pathological conditions. Leroy, K., Duyckaerts, C., Bovekamp, L., Müller, O., Anderton, B.H., Brion, J.P. Acta Neuropathol. (2001) [Pubmed]
  7. Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity. Etienne-Manneville, S., Hall, A. Nature (2003) [Pubmed]
  8. Effects of dietary folate on DNA strand breaks within mutation-prone exons of the p53 gene in rat colon. Kim, Y.I., Shirwadkar, S., Choi, S.W., Puchyr, M., Wang, Y., Mason, J.B. Gastroenterology (2000) [Pubmed]
  9. The effect of dietary folate on Apc and p53 mutations in the dimethylhydrazine rat model of colorectal cancer. Sohn, K.J., Puchyr, M., Salomon, R.N., Graeme-Cook, F., Fung, L., Choi, S.W., Mason, J.B., Medline, A., Kim, Y.I. Carcinogenesis (1999) [Pubmed]
  10. Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthetase? Alberts, D.S., Hixson, L., Ahnen, D., Bogert, C., Einspahr, J., Paranka, N., Brendel, K., Gross, P.H., Pamukcu, R., Burt, R.W. J. Cell. Biochem. Suppl. (1995) [Pubmed]
  11. Beta-catenin, an inducer of uncontrolled cell proliferation and migration in malignancies, is localized in the cytoplasm of vascular endothelium during neovascularization after myocardial infarction. Blankesteijn, W.M., van Gijn, M.E., Essers-Janssen, Y.P., Daemen, M.J., Smits, J.F. Am. J. Pathol. (2000) [Pubmed]
  12. Subcellular localization of the tumor suppressor protein APC in developing cultured neurons. Shimomura, A., Kohu, K., Akiyama, T., Senda, T. Neurosci. Lett. (2005) [Pubmed]
  13. Cdc42 and Par6-PKCzeta regulate the spatially localized association of Dlg1 and APC to control cell polarization. Etienne-Manneville, S., Manneville, J.B., Nicholls, S., Ferenczi, M.A., Hall, A. J. Cell Biol. (2005) [Pubmed]
  14. Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: mutational 'hotspots' and the relative expression of beta-catenin and c-jun. Blum, C.A., Tanaka, T., Zhong, X., Li, Q., Dashwood, W.M., Pereira, C., Xu, M., Dashwood, R.H. Mol. Carcinog. (2003) [Pubmed]
  15. Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Kakiuchi, H., Watanabe, M., Ushijima, T., Toyota, M., Imai, K., Weisburger, J.H., Sugimura, T., Nagao, M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  16. Mutations of the Apc gene in experimental colorectal carcinogenesis induced by azoxymethane in F344 rats. De Filippo, C., Caderni, G., Bazzicalupo, M., Briani, C., Giannini, A., Fazi, M., Dolara, P. Br. J. Cancer (1998) [Pubmed]
  17. The influence of 1-aminocyclopentane-1-carboxylic acid at position 2 or 3 of AVP and its analogues on their pharmacological properties. Kowalczyk, W., Prahl, A., Dawidowska, O., Derdowska, I., Sobolewski, D., Hartrodt, B., Neubert, K., Slaninová, J., Lammek, B. J. Pept. Sci. (2005) [Pubmed]
  18. Changes in WNT/beta-catenin pathway during regulated growth in rat liver regeneration. Monga, S.P., Pediaditakis, P., Mule, K., Stolz, D.B., Michalopoulos, G.K. Hepatology (2001) [Pubmed]
  19. Strain differences of rats in the susceptibility to aberrant crypt foci formation by 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine: no implication of Apc and Pla2g2a genetic polymorphisms in differential susceptibility. Ishiguro, Y., Ochiai, M., Sugimura, T., Nagao, M., Nakagama, H. Carcinogenesis (1999) [Pubmed]
  20. Suppression of beta-catenin by antisense oligomers augments tumor response to isolated limb perfusion in a rodent model of adenomatous polyposis coli-mutant colon cancer. Canter, R.J., Kesmodel, S.B., Heitjan, D.F., Veeramachaneni, N.K., Mokadam, N.A., Drebin, J.A., Fraker, D.L. Ann. Surg. Oncol. (2005) [Pubmed]
  21. How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men. Corpet, D.E., Pierre, F. Eur. J. Cancer (2005) [Pubmed]
  22. Absence of PhIP adducts, p53 and Apc mutations, in rats fed a cooked beef diet containing a high level of heterocyclic amines. Shen, C.L., Purewal, M., San Francisco, S., Pence, B.C. Nutrition and cancer. (1998) [Pubmed]
  23. Modeling human colon cancer in rodents using a food-borne carcinogen, PhIP. Nakagama, H., Nakanishi, M., Ochiai, M. Cancer Sci. (2005) [Pubmed]
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