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Gene Review:

RA3 - Rheumatoid arthritis QTL 02

Homo sapiens

Onorati, F. et al., Shiozawa, S. et al., Lee, Y.H. et al.

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High impact information on RA3

METHODS: From January 2001 to January 2004 188 patients undergoing coronary artery bypass graft with RA were divided into three groups: harmonic scalpel was employed in 61 (RA1), electrocautery in 63 (RA2), Potts-scissors and clips in 64 (RA3) patients [1].
No RA1 patient underwent re-exploration for bleeding compared to RA2 (p = 0.011) and RA3 (p = 0.02) [1].
He had been diagnosed as having RA 3 years previously and had been receiving 200 mg of bucillamine for 21 months [2].

Biological context of RA3

We are now assigning the death receptor 3 as a candidate gene for RA1, and the truncated form of Dbl proto-oncogene, which does not contain the 23rd and 24th exons, as disease gene for RA3 [3].

References

Can harvesting techniques modify postoperative results of the radial artery conduit? Onorati, F., De Feo, M., Cristodoro, L., Esposito, A., Perrotti, A., Mastroroberto, P., Renzulli, A., Cotrufo, M. Italian heart journal : official journal of the Italian Federation of Cardiology. (2005) [Pubmed]
A case of BOOP developed during bucillamine treatment for rheumatoid. Lee, Y.H., Kim, Y.R., Ji, J.D., Shim, J.J., Kang, K.H., Lee, J.H., Kim, H.K., Song, G.G. Korean J. Intern. Med. (2001) [Pubmed]
An approach to identify new genes in autoimmune diseases: lessons from rheumatoid arthritis. Shiozawa, S., Komai, K., Konishi, Y., Hikasa, M., Mukae, N., Shiozawa, K., Kitagawa, M., Yoshikawa, N., Kawasaki, H. Reviews in immunogenetics. (2000) [Pubmed]

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