Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

RA2 - Rheumatoid arthritis QTL 01

Homo sapiens

Berggrun, A. et al., Bunney, T.D. et al., Onorati, F. et al., Ebeling, H. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of RA2

Postoperative hand paresthesia was detected in RA1 (5/61; 8.2%) and RA2 (5/63; 7.9%), but not in RA3 (p = 0.048 and p = 0.05, respectively) [1].

Psychiatry related information on RA2

Among girls, regular alcohol consumption was more common among those who previously had behavioural or mixed type problems (according to the RA2), 70.7%, as compared to those who previously had emotional or no problems, 12.2% [2].

High impact information on RA2

Although the similarity between ubiquitin-like folds of RA1 and RA2 proves that they are homologs, only RA2 can bind ras [3].
Double-mutant thermodynamic cycle analyses using the RA2, RM2, and operator variants also reveal interaction free energies between Arg2 and operator base-pairs 9, 10, 11, 12 and 13, which in aggregate account for most of the Arg2 contribution to operator binding [4].
No RA1 patient underwent re-exploration for bleeding compared to RA2 (p = 0.011) and RA3 (p = 0.02) [1].

Analytical, diagnostic and therapeutic context of RA2

We solved structures of PLCepsilon RA domains (RA1 and RA2) by NMR and the structure of the RA2/ras complex by X-ray crystallography [3].

References

Can harvesting techniques modify postoperative results of the radial artery conduit? Onorati, F., De Feo, M., Cristodoro, L., Esposito, A., Perrotti, A., Mastroroberto, P., Renzulli, A., Cotrufo, M. Italian heart journal : official journal of the Italian Federation of Cardiology. (2005) [Pubmed]
Smoking and drinking habits in adolescence--links with psychiatric disturbance at the age of 8 years. Ebeling, H., Moilanen, I., Linna, S.L., Tirkkonen, T., Ebeling, T., Piha, J., Kumpulainen, K., Räsänen, E., Tamminen, T., Almqvist, F. European child & adolescent psychiatry. (1999) [Pubmed]
Structural and mechanistic insights into ras association domains of phospholipase C epsilon. Bunney, T.D., Harris, R., Gandarillas, N.L., Josephs, M.B., Roe, S.M., Sorli, S.C., Paterson, H.F., Rodrigues-Lima, F., Esposito, D., Ponting, C.P., Gierschik, P., Pearl, L.H., Driscoll, P.C., Katan, M. Mol. Cell (2006) [Pubmed]
Interactions of Arg2 in the Mnt N-terminal arm with the central and flanking regions of the Mnt operator. Berggrun, A., Sauer, R.T. J. Mol. Biol. (2000) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.