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MeSH Review

Proto-Oncogenes

 
 
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Disease relevance of Proto-Oncogenes

 

Psychiatry related information on Proto-Oncogenes

 

High impact information on Proto-Oncogenes

  • It is now evident that IL-2R beta is linked to at least two intracellular signalling pathways that mediate nuclear proto-oncogene induction [7].
  • These findings suggest that the loss of the proto-oncogene Nras in certain cellular contexts can promote malignant tumor progression [8].
  • Localized signals known as 'organizers' and members of the Pax family of proto-oncogenes are both elements in this control [9].
  • These results identify a new mechanism of regulation of the proto-oncogene BCL6 with potential for therapeutic exploitation [3].
  • Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice [10].
 

Chemical compound and disease context of Proto-Oncogenes

 

Biological context of Proto-Oncogenes

 

Anatomical context of Proto-Oncogenes

 

Associations of Proto-Oncogenes with chemical compounds

 

Gene context of Proto-Oncogenes

  • Although the ras genes have long been established as proto-oncogenes, the dominant role of activated ras in cell transformation has been questioned [30].
  • Mutations at the steel locus (Sl) of the mouse affect the same cellular targets as mutations at the white spotting locus (W), which is allelic with the c-kit proto-oncogene [31].
  • The trk proto-oncogene encodes a receptor for nerve growth factor [32].
  • Recent findings demonstrating that W encodes the c-kit proto-oncogene, a tyrosine kinase membrane receptor, have suggested that Sl encodes a ligand for c-kit [33].
  • One of the signaling pathways that operates to specify positional information throughout the segment is mediated by the wingless (wg) protein, which is the homolog of the proto-oncogene Wnt-1 [34].
 

Analytical, diagnostic and therapeutic context of Proto-Oncogenes

References

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  16. The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Allsopp, T.E., Wyatt, S., Paterson, H.F., Davies, A.M. Cell (1993) [Pubmed]
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  18. IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: demonstration of a novel role for c-myc. Shibuya, H., Yoneyama, M., Ninomiya-Tsuji, J., Matsumoto, K., Taniguchi, T. Cell (1992) [Pubmed]
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  24. Functional receptor for GDNF encoded by the c-ret proto-oncogene. Trupp, M., Arenas, E., Fainzilber, M., Nilsson, A.S., Sieber, B.A., Grigoriou, M., Kilkenny, C., Salazar-Grueso, E., Pachnis, V., Arumäe, U. Nature (1996) [Pubmed]
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