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Gene Review

SMAD4  -  SMAD family member 4

Canis lupus familiaris

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High impact information on SMAD4

  • However, we found no evidence in this system that ERK can significantly influence the function of Smad2, Smad3, and Smad4 at the level of nuclear translocation, DNA binding, or transcriptional activation [1].


  1. Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells. Lehmann, K., Janda, E., Pierreux, C.E., Rytömaa, M., Schulze, A., McMahon, M., Hill, C.S., Beug, H., Downward, J. Genes Dev. (2000) [Pubmed]
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