Gene Review:
SMAD4 - SMAD family member 4
Homo sapiens
Synonyms:
DPC4, Deletion target in pancreatic carcinoma 4, JIP, MAD homolog 4, MADH4, ...
Hemmati,
Karatsaidis,
Liang,
Liu,
Poncelet,
He,
Schenck,
Fukushima,
Yu,
Endo,
Mashiko,
Ruddle,
Xu,
Hirai,
Takenoshita,
Leng,
Shimizu,
Roylance,
Takeshita,
Chen,
Schnaper,
Wills,
Ajmera,
Rahman,
Avanzini,
Chiba,
Masuda,
Hsieh,
Imai,
Sekikawa,
Wei,
Lu,
Bodmer,
Zou,
de Caestecker,
Atencio,
Schreurs,
Helgeland,
Peng,
Lechleider,
Wasan,
Halford,
Chiou,
Lin,
Ho,
Woodford-Richens,
Hung,
Rowan,
Nakamura,
Roberts,
David K Crockett,
Axéll,
Kurokawa,
Gorman,
Ramachandra,
Vaillancourt,
Tomlinson,
Shabram,
Bicknell,
Takita,
Bookstein,
Larisch-Bloch,
Kumano,
Otake,
de Caestecker,
- Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Bardeesy, N., Cheng, K.H., Berger, J.H., Chu, G.C., Pahler, J., Olson, P., Hezel, A.F., Horner, J., Lauwers, G.Y., Hanahan, D., Depinho, R.A. Genes Dev. (2006)
- SMAD4 mutations in colorectal cancer probably occur before chromosomal instability, but after divergence of the microsatellite instability pathway. Woodford-Richens, K.L., Rowan, A.J., Gorman, P., Halford, S., Bicknell, D.C., Wasan, H.S., Roylance, R.R., Bodmer, W.F., Tomlinson, I.P. Proc. Natl. Acad. Sci. U.S.A. (2001)
- A novel SMAD4 gene mutation in seminoma germ cell tumors. Bouras, M., Tabone, E., Bertholon, J., Sommer, P., Bouvier, R., Droz, J.P., Benahmed, M. Cancer Res. (2000)
- Allelic analysis of serous ovarian carcinoma reveals two putative tumor suppressor loci at 18q22-q23 distal to SMAD4, SMAD2, and DCC. Lassus, H., Salovaara, R., Aaltonen, L.A., Butzow, R. Am. J. Pathol. (2001)
- SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer. Blackford, A., Serrano, O.K., Wolfgang, C.L., Parmigiani, G., Jones, S., Zhang, X., Parsons, D.W., Lin, J.C., Leary, R.J., Eshleman, J.R., Goggins, M., Jaffee, E.M., Iacobuzio-Donahue, C.A., Maitra, A., Cameron, J.L., Olino, K., Schulick, R., Winter, J., Herman, J.M., Laheru, D., Klein, A.P., Vogelstein, B., Kinzler, K.W., Velculescu, V.E., Hruban, R.H. Clin. Cancer Res. (2009)
- SMAD4 immunohistochemistry reflects genetic status in juvenile polyposis syndrome. Langeveld, D., van Hattem, W.A., de Leng, W.W., Morsink, F.H., Ten Kate, F.J., Giardiello, F.M., Offerhaus, G.J., Brosens, L.A. Clin. Cancer Res. (2010)
- c-Jun N-terminal kinase (JNK)-interacting protein-1b/islet-brain-1 scaffolds Alzheimer's amyloid precursor protein with JNK. Matsuda, S., Yasukawa, T., Homma, Y., Ito, Y., Niikura, T., Hiraki, T., Hirai, S., Ohno, S., Kita, Y., Kawasumi, M., Kouyama, K., Yamamoto, T., Kyriakis, J.M., Nishimoto, I. J. Neurosci. (2001)
- SMAD4-deficient intestinal tumors recruit CCR1(+) myeloid cells that promote invasion. Kitamura, T., Kometani, K., Hashida, H., Matsunaga, A., Miyoshi, H., Hosogi, H., Aoki, M., Oshima, M., Hattori, M., Takabayashi, A., Minato, N., Taketo, M.M. Nat. Genet. (2007)
- Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway. He, W., Dorn, D.C., Erdjument-Bromage, H., Tempst, P., Moore, M.A., Massagué, J. Cell (2006)
- Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Dupont, S., Zacchigna, L., Cordenonsi, M., Soligo, S., Adorno, M., Rugge, M., Piccolo, S. Cell (2005)
- A Smad transcriptional corepressor. Wotton, D., Lo, R.S., Lee, S., Massagué, J. Cell (1999)
- Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway. Xu, J., Attisano, L. Proc. Natl. Acad. Sci. U.S.A. (2000)
- SMAD4 levels and response to 5-fluorouracil in colorectal cancer. Alhopuro, P., Alazzouzi, H., Sammalkorpi, H., Dávalos, V., Salovaara, R., Hemminki, A., Järvinen, H., Mecklin, J.P., Schwartz, S., Aaltonen, L.A., Arango, D. Clin. Cancer Res. (2005)
- Smad4 as a transcription corepressor for estrogen receptor alpha. Wu, L., Wu, Y., Gathings, B., Wan, M., Li, X., Grizzle, W., Liu, Z., Lu, C., Mao, Z., Cao, X. J. Biol. Chem. (2003)
- Loss of Smad4 protein expression occurs infrequently in endometrial carcinomas. Liu, F.S., Chen, J.T., Hsieh, Y.T., Ho, E.S., Hung, M.J., Lu, C.H., Chiou, L.C. Int. J. Gynecol. Pathol. (2003)
- Inhibitory effect of retroviral vector containing anti-sense Smad4 gene on Ito cell line, LI90. Xu, X.B., Leng, X.S., He, Z.P., Liang, Z.Q., Lin, K., Wei, Y.H., Yu, X., Peng, J.R. Chin. Med. J. (2004)
- Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. Xu, X., Kobayashi, S., Qiao, W., Li, C., Xiao, C., Radaeva, S., Stiles, B., Wang, R.H., Ohara, N., Yoshino, T., LeRoith, D., Torbenson, M.S., Gores, G.J., Wu, H., Gao, B., Deng, C.X. J. Clin. Invest. (2006)
- Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes. Zhou, X.P., Woodford-Richens, K., Lehtonen, R., Kurose, K., Aldred, M., Hampel, H., Launonen, V., Virta, S., Pilarski, R., Salovaara, R., Bodmer, W.F., Conrad, B.A., Dunlop, M., Hodgson, S.V., Iwama, T., Järvinen, H., Kellokumpu, I., Kim, J.C., Leggett, B., Markie, D., Mecklin, J.P., Neale, K., Phillips, R., Piris, J., Rozen, P., Houlston, R.S., Aaltonen, L.A., Tomlinson, I.P., Eng, C. Am. J. Hum. Genet. (2001)
- SMAD3/4-dependent transcriptional activation of the human type VII collagen gene (COL7A1) promoter by transforming growth factor beta. Vindevoghel, L., Lechleider, R.J., Kon, A., de Caestecker, M.P., Uitto, J., Roberts, A.B., Mauviel, A. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Hyaluronan attenuates transforming growth factor-beta1-mediated signaling in renal proximal tubular epithelial cells. Ito, T., Williams, J.D., Fraser, D., Phillips, A.O. Am. J. Pathol. (2004)
- SMAD proteins transactivate the human ApoCIII promoter by interacting physically and functionally with hepatocyte nuclear factor 4. Kardassis, D., Pardali, K., Zannis, V.I. J. Biol. Chem. (2000)
- SMAD4/DPC4 expression and prognosis in human colorectal cancer. Isaksson-Mettävainio, M., Palmqvist, R., Forssell, J., Stenling, R., Oberg, A. Anticancer Res. (2006)
- Smad4 dependency defines two classes of transforming growth factor {beta} (TGF-{beta}) target genes and distinguishes TGF-{beta}-induced epithelial-mesenchymal transition from its antiproliferative and migratory responses. Levy, L., Hill, C.S. Mol. Cell. Biol. (2005)
- Restoration of transforming growth factor Beta signaling by functional expression of smad4 induces anoikis. Ramachandra, M., Atencio, I., Rahman, A., Vaillancourt, M., Zou, A., Avanzini, J., Wills, K., Bookstein, R., Shabram, P. Cancer Res. (2002)
- Characterization of functional domains within Smad4/DPC4. de Caestecker, M.P., Hemmati, P., Larisch-Bloch, S., Ajmera, R., Roberts, A.B., Lechleider, R.J. J. Biol. Chem. (1997)
- Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. Dennler, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S., Gauthier, J.M. EMBO J. (1998)
- The transforming growth factor-beta/SMAD signaling pathway is present and functional in human mesangial cells. Poncelet, A.C., de Caestecker, M.P., Schnaper, H.W. Kidney Int. (1999)
- CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription. Li, L., Xin, H., Xu, X., Huang, M., Zhang, X., Chen, Y., Zhang, S., Fu, X.Y., Chang, Z. Mol. Cell. Biol. (2004)
- Activation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4. Lin, X., Liang, M., Liang, Y.Y., Brunicardi, F.C., Melchior, F., Feng, X.H. J. Biol. Chem. (2003)
- DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. Wu, K., Yang, Y., Wang, C., Davoli, M.A., D'Amico, M., Li, A., Cveklova, K., Kozmik, Z., Lisanti, M.P., Russell, R.G., Cvekl, A., Pestell, R.G. J. Biol. Chem. (2003)
- Inhibition of the transforming growth factor-beta/Smad signaling pathway in the epithelium of oral lichen. Karatsaidis, A., Schreurs, O., Axéll, T., Helgeland, K., Schenck, K. J. Invest. Dermatol. (2003)
- Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells. Chiba, S., Takeshita, K., Imai, Y., Kumano, K., Kurokawa, M., Masuda, S., Shimizu, K., Nakamura, S., Ruddle, F.H., Hirai, H. Proc. Natl. Acad. Sci. U.S.A. (2003)
- Mutational analysis of TGF-beta type II receptor, Smad2, Smad3, Smad4, Smad6 and Smad7 genes in colorectal cancer. Fukushima, T., Mashiko, M., Takita, K., Otake, T., Endo, Y., Sekikawa, K., Takenoshita, S. J. Exp. Clin. Cancer Res. (2003)
- Sumoylation of Smad4, the common Smad mediator of transforming growth factor-beta family signaling. Lee, P.S., Chang, C., Liu, D., Derynck, R. J. Biol. Chem. (2003)
- Smad4-dependent TGF-beta signaling suppresses RON receptor tyrosine kinase-dependent motility and invasion of pancreatic cancer cells. Zhao, S., Ammanamanchi, S., Brattain, M., Cao, L., Thangasamy, A., Wang, J., Freeman, J.W. J. Biol. Chem. (2008)
- Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Hata, A., Lo, R.S., Wotton, D., Lagna, G., Massagué, J. Nature (1997)
- TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. Nakao, A., Imamura, T., Souchelnytskyi, S., Kawabata, M., Ishisaki, A., Oeda, E., Tamaki, K., Hanai, J., Heldin, C.H., Miyazono, K., ten Dijke, P. EMBO J. (1997)
- Differential expression of a novel C-terminally truncated splice form of SMAD5 in hematopoietic stem cells and leukemia. Jiang, Y., Liang, H., Guo, W., Kottickal, L.V., Nagarajan, L. Blood (2000)
- MDM2 and MDMX inhibit the transcriptional activity of ectopically expressed SMAD proteins. Yam, C.H., Siu, W.Y., Arooz, T., Chiu, C.H., Lau, A., Wang, X.Q., Poon, R.Y. Cancer Res. (1999)
- Different pattern of allelic loss in Epstein-Barr virus-positive gastric cancer with emphasis on the p53 tumor suppressor pathway. van Rees, B.P., Caspers, E., zur Hausen, A., van den Brule, A., Drillenburg, P., Weterman, M.A., Offerhaus, G.J. Am. J. Pathol. (2002)
- Up-regulation of transforming growth factor (TGF)-beta receptors by TGF-beta1 in COLO-357 cells. Kleeff, J., Korc, M. J. Biol. Chem. (1998)
- Impaired transforming growth factor beta signalling in Barrett's carcinogenesis due to frequent SMAD4 inactivation. Onwuegbusi, B.A., Aitchison, A., Chin, S.F., Kranjac, T., Mills, I., Huang, Y., Lao-Sirieix, P., Caldas, C., Fitzgerald, R.C. Gut (2006)