Gene Review:
Smad4 - SMAD family member 4
Rattus norvegicus
Synonyms:
MAD homolog 4, Madh4, Mothers against DPP homolog 4, Mothers against decapentaplegic homolog 4, SMAD 4
- Smad2 overexpression enhances Smad4 gene expression and suppresses CBFA1 gene expression in osteoblastic osteosarcoma ROS17/2.8 cells and primary rat calvaria cells. Li, J., Tsuji, K., Komori, T., Miyazono, K., Wrana, J.L., Ito, Y., Nifuji, A., Noda, M. J. Biol. Chem. (1998)
- Mutations of the Smad2 and Smad4 genes in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Tsujiuchi, T., Sasaki, Y., Tsutsumi, M., Konishi, Y. Mol. Carcinog. (2000)
- SMAD pathway mediation of BDNF and TGF beta 2 regulation of proliferation and differentiation of hippocampal granule neurons. Lu, J., Wu, Y., Sousa, N., Almeida, O.F. Development (2005)
- Increased smad expression and activation are associated with apoptosis in normal and malignant prostate after castration. Brodin, G., ten Dijke, P., Funa, K., Heldin, C.H., Landström, M. Cancer Res. (1999)
- Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta ) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent. Liu, C., Gaça, M.D., Swenson, E.S., Vellucci, V.F., Reiss, M., Wells, R.G. J. Biol. Chem. (2003)
- Localization of Smads, the TGF-beta family intracellular signaling components during endochondral ossification. Sakou, T., Onishi, T., Yamamoto, T., Nagamine, T., Sampath, T., Ten Dijke, P. J. Bone Miner. Res. (1999)
- Activation of TGF-beta-Smad signaling pathway following polyamine depletion in intestinal epithelial cells. Liu, L., Santora, R., Rao, J.N., Guo, X., Zou, T., Zhang, H.M., Turner, D.J., Wang, J.Y. Am. J. Physiol. Gastrointest. Liver Physiol. (2003)
- Transforming growth factor beta (TGF-beta) signaling is regulated by electrical activity in skeletal muscle cells. TGF-beta type I receptor is transcriptionally regulated by myotube excitability. Ugarte, G., Brandan, E. J. Biol. Chem. (2006)
- Expression and localization of the transforming growth factor-beta type I receptor and Smads in preneoplastic lesions during chemical hepatocarcinogenesis in rats. Park, d.o. .Y., Lee, C.H., Sol, M.Y., Suh, K.S., Yoon, S.Y., Kim, J.W. J. Korean Med. Sci. (2003)
- Expression of Smad2 and Smad4, transforming growth factor-beta signal transducers in rat endometrium during the estrous cycle, pre-, and peri-implantation. Lin, H.Y., Wang, H.M., Li, Q.L., Liu, D.L., Zhang, X., Liu, G.Y., Qian, D., Zhu, C. Anim. Reprod. Sci. (2004)
- Alterations of the transforming growth factor-beta signaling pathway in hepatocellular carcinomas induced endogenously and exogenously in rats. Sasaki, Y., Tsujiuchi, T., Murata, N., Tsutsumi, M., Konishi, Y. Jpn. J. Cancer Res. (2001)
- TGF-beta control of rat thyroid follicular cells differentiation. Nicolussi, A., D'Inzeo, S., Santulli, M., Colletta, G., Coppa, A. Mol. Cell. Endocrinol. (2003)
- Expression and localization of Smad1, Smad2 and Smad4 proteins in rat testis during postnatal development. Hu, J., Zhang, Y.Q., Liu, X.P., Wang, R.A., Jin, Y., Xu, R.J. Asian J. Androl. (2003)
- PPARalpha inhibits TGF-beta-induced beta5 integrin transcription in vascular smooth muscle cells by interacting with Smad4. Kintscher, U., Lyon, C., Wakino, S., Bruemmer, D., Feng, X., Goetze, S., Graf, K., Moustakas, A., Staels, B., Fleck, E., Hsueh, W.A., Law, R.E. Circ. Res. (2002)
- Angiotensin II promotes the proliferation of activated pancreatic stellate cells by Smad7 induction through a protein kinase C pathway. Hama, K., Ohnishi, H., Aoki, H., Kita, H., Yamamoto, H., Osawa, H., Sato, K., Tamada, K., Mashima, H., Yasuda, H., Sugano, K. Biochem. Biophys. Res. Commun. (2006)
- Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro. Hao, J., Wang, B., Jones, S.C., Jassal, D.S., Dixon, I.M. Am. J. Physiol. Heart Circ. Physiol. (2000)
- Smad4 mediates activation of mitogen-activated protein kinases by TGF-beta in pancreatic acinar cells. Simeone, D.M., Zhang, L., Graziano, K., Nicke, B., Pham, T., Schaefer, C., Logsdon, C.D. Am. J. Physiol., Cell Physiol. (2001)
- Matrix metalloproteinase 2 activation of transforming growth factor-beta1 (TGF-beta1) and TGF-beta1-type II receptor signaling within the aged arterial wall. Wang, M., Zhao, D., Spinetti, G., Zhang, J., Jiang, L.Q., Pintus, G., Monticone, R., Lakatta, E.G. Arterioscler. Thromb. Vasc. Biol. (2006)
- Signaling by bone morphogenetic proteins and Smad1 modulates the postnatal differentiation of cerebellar cells. Angley, C., Kumar, M., Dinsio, K.J., Hall, A.K., Siegel, R.E. J. Neurosci. (2003)
- Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway. Akool, e.l.-.S., Doller, A., Müller, R., Gutwein, P., Xin, C., Huwiler, A., Pfeilschifter, J., Eberhardt, W. J. Biol. Chem. (2005)