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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TPP1  -  tripeptidyl peptidase I

Canis lupus familiaris

 
 
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High impact information on TPP1

  • A frame shift mutation in canine TPP1 (the ortholog of human CLN2) in a juvenile Dachshund with neuronal ceroid lipofuscinosis [1].
  • Nucleotide sequence analysis of canine TPP1, the ortholog of human CLN2, revealed a single nucleotide deletion in exon 4 which predicted a frame shift with a premature stop codon [1].
  • The model presented here indicates a very open and accessible active site that is almost completely conserved among all known CLN2 enzymes [2].
  • CONCLUSION: CLN2 is very highly conserved and widely distributed among higher organisms and may play an important role in their life cycles [2].

References

  1. A frame shift mutation in canine TPP1 (the ortholog of human CLN2) in a juvenile Dachshund with neuronal ceroid lipofuscinosis. Awano, T., Katz, M.L., O'brien, D.P., Sohar, I., Lobel, P., Coates, J.R., Khan, S., Johnson, G.C., Giger, U., Johnson, G.S. Mol. Genet. Metab. (2006) [Pubmed]
  2. A model of tripeptidyl-peptidase I (CLN2), a ubiquitous and highly conserved member of the sedolisin family of serine-carboxyl peptidases. Wlodawer, A., Durell, S.R., Li, M., Oyama, H., Oda, K., Dunn, B.M. BMC Struct. Biol. (2003) [Pubmed]
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