Gene Review:
Nrtim1 - neurotensin immunoreactivity 1
Mus musculus
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High impact information on Nrtim1
- Levels of NT-ir were higher in hypothalamus and midbrain from long-sleep (LS) than from short-sleep (SS) mice [1].
- The highest levels of NT-ir were observed in the hypothalamus with intermediate levels in the midbrain and striatum and lowest levels in the frontal cortex [1].
- Levels of NT-ir in the frontal cortex were not altered by ethanol administration [1].
- Ethanol-induced decreases in NT-ir were of rapid onset with a maximum decrease in 5 min after intraperitoneal (i.p.) injection, and they were of long duration with levels remaining depressed for 4 hr [1].
Analytical, diagnostic and therapeutic context of Nrtim1
- Neurotensin-immunoreactivity (NT-ir) was extracted from various brain regions and shown by high performance liquid chromatography to possess the same retention time as authentic bovine NT1-13 [1].
References
- Low doses of ethanol reduce neurotensin levels in discrete brain regions from LS/Ibg and SS/Ibg mice. Erwin, V.G., Jones, B.C., Radcliffe, R. Alcohol. Clin. Exp. Res. (1990) [Pubmed]
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