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Gene Review:

TSHR - thyroid stimulating hormone receptor

Felis catus

Kala, M. et al., Peeters, M.E. et al.

Peeters, Timmermans-Sprang, Mol,

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Disease relevance of TSHR

This work suggests that mutations in the extracellular or transmembrane part of the TSHR gene are not likely the cause of feline hyperthyroidism [1].
Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease [2].
TSHR adenovirus immunized mice develop Th1 T cells, TSHR antibodies, and a proportion become overtly hyperthyroid [2].

High impact information on TSHR

These data imply that loading of TSHR peptides critical to TSHR antibody responses becomes Ii-independent [2].

References

Feline thyroid adenomas are in part associated with mutations in the G(s alpha) gene and not with polymorphisms found in the thyrotropin receptor. Peeters, M.E., Timmermans-Sprang, E.P., Mol, J.A. Thyroid (2002) [Pubmed]
Cathepsin S is not crucial to TSHR processing and presentation in a murine model of Graves' disease. Kala, M., Chen, C.R., McLachlan, S.M., Rapoport, B., Aliesky, H., Chapman, H.A. Immunology (2005) [Pubmed]

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