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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Hyperthyroidism


Psychiatry related information on Hyperthyroidism


High impact information on Hyperthyroidism


Chemical compound and disease context of Hyperthyroidism


Biological context of Hyperthyroidism


Anatomical context of Hyperthyroidism


Gene context of Hyperthyroidism

  • Herein, we report the molecular characterization of a case of severe congenital hyperthyroidism with a history of hyperthyroidism in the paternal aunt and the paternal grandmother, who were both found to be heterozygous for a mutation (R528H) located in exon 10 of the TSHR gene [27].
  • Juvenile hyperthyroidism with elevated thyrotropin (TSH) and normal 24 hour FSH, LH, GH and prolactin secretory patterns [28].
  • Altered GH responses to several pharmacological stimuli, including GHRH, have been found in hyperthyroidism [29].
  • HL (P < 0.05) and CETP activities (P < 0.05) were elevated in hyperthyroidism and reduced in hypothyroidism (P < 0.05, P < 0.01 respectively) and both were related to free T4 levels [30].
  • Our results showed that 56% of wild-type, 75% of Stat4-/-, and 39% of Stat6-/- mice developed hyperthyroidism [31].

Analytical, diagnostic and therapeutic context of Hyperthyroidism


  1. Lack of effect of thyroxine in patients with Graves' hyperthyroidism who are treated with an antithyroid drug. McIver, B., Rae, P., Beckett, G., Wilkinson, E., Gold, A., Toft, A. N. Engl. J. Med. (1996) [Pubmed]
  2. Occurrence of ophthalmopathy after treatment for Graves' hyperthyroidism. The Thyroid Study Group. Tallstedt, L., Lundell, G., Tørring, O., Wallin, G., Ljunggren, J.G., Blomgren, H., Taube, A. N. Engl. J. Med. (1992) [Pubmed]
  3. Incidence of thyroid cancer in women in relation to previous exposure to radiation therapy and history of thyroid disease. McTiernan, A.M., Weiss, N.S., Daling, J.R. J. Natl. Cancer Inst. (1984) [Pubmed]
  4. Breast cancer following iodine-131 therapy for hyperthyroidism. Hoffman, D.A., McConahey, W.M. J. Natl. Cancer Inst. (1983) [Pubmed]
  5. Demonstration of a circulating autoantibody against a soluble eye-muscle antigen in Graves' ophthalmopathy. Kodama, K., Sikorska, H., Bandy-Dafoe, P., Bayly, R., Wall, J.R. Lancet (1982) [Pubmed]
  6. Inhibitory action of thyrotropin-releasing hormone on serum amylase activity and its mechanism. Komiya, I., Yamada, T., Kanno, Y., Aizawa, T., Hashizume, K., Yamagishi, F., Iijima, F., Iwatsuki, K., Chiba, S. J. Clin. Endocrinol. Metab. (1984) [Pubmed]
  7. Influence of neonatal and adult hyperthyroidism on behavior and biosynthetic capacity for norepinephrine, dopamine and 5-hydroxytryptamine in rat brain. Rastogi, R.B., Singhal, R.L. J. Pharmacol. Exp. Ther. (1976) [Pubmed]
  8. Hyperthyroidism six years post-BMT for acute myeloblastic leukemia in a patient on long-term lithium therapy for bipolar affective disorder. Law, A., Rifkind, J., Rosen, F., Lipton, J.H. Leuk. Lymphoma (2004) [Pubmed]
  9. Molecular analysis of the sodium/iodide symporter: impact on thyroid and extrathyroid pathophysiology. De La Vieja, A., Dohan, O., Levy, O., Carrasco, N. Physiol. Rev. (2000) [Pubmed]
  10. Relation between therapy for hyperthyroidism and the course of Graves' ophthalmopathy. Bartalena, L., Marcocci, C., Bogazzi, F., Manetti, L., Tanda, M.L., Dell'Unto, E., Bruno-Bossio, G., Nardi, M., Bartolomei, M.P., Lepri, A., Rossi, G., Martino, E., Pinchera, A. N. Engl. J. Med. (1998) [Pubmed]
  11. Response of thyrotropin-secreting pituitary adenomas to a long-acting somatostatin analogue. Comi, R.J., Gesundheit, N., Murray, L., Gorden, P., Weintraub, B.D. N. Engl. J. Med. (1987) [Pubmed]
  12. Abnormal left ventricular function in hyperthyroidism: evidence for a possible reversible cardiomyopathy. Forfar, J.C., Muir, A.L., Sawers, S.A., Toft, A.D. N. Engl. J. Med. (1982) [Pubmed]
  13. Carbimazole and the autoimmune response in Graves' disease. McGregor, A.M., Petersen, M.M., McLachlan, S.M., Rooke, P., Smith, B.R., Hall, R. N. Engl. J. Med. (1980) [Pubmed]
  14. Pindolol and hyperthyroidism. Abadie, E., Leclercq, J.F., Passa, P. N. Engl. J. Med. (1983) [Pubmed]
  15. Thyroxine toxicosis. A common variant of hyperthyroidism. Caplan, R.H., Pagliara, A.S., Wickus, G. JAMA (1980) [Pubmed]
  16. Landmark article May 8, 1943: Treatment of hyperthyroidism with thiourea and thiouracil. By E.B. Astwood. Astwood, E.B. JAMA (1984) [Pubmed]
  17. Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline. Thomas, S.A., Palmiter, R.D. Nature (1997) [Pubmed]
  18. Mechanisms of impaired exercise capacity in short duration experimental hyperthyroidism. Martin, W.H., Spina, R.J., Korte, E., Yarasheski, K.E., Angelopoulos, T.J., Nemeth, P.M., Saffitz, J.E. J. Clin. Invest. (1991) [Pubmed]
  19. Thyroid expression of an A2 adenosine receptor transgene induces thyroid hyperplasia and hyperthyroidism. Ledent, C., Dumont, J.E., Vassart, G., Parmentier, M. EMBO J. (1992) [Pubmed]
  20. Axial bone mass in older women. Study of Osteoporotic Fractures Research Group. Orwoll, E.S., Bauer, D.C., Vogt, T.M., Fox, K.M. Ann. Intern. Med. (1996) [Pubmed]
  21. Hyperthyroidism impairs pancreatic beta cell adaptations to late pregnancy and maternal liporegulation in the rat. Holness, M.J., Greenwood, G.K., Smith, N.D., Sugden, M.C. Diabetologia (2005) [Pubmed]
  22. Erythrocyte zinc concentration in patients with subacute thyroiditis. Yoshida, K., Kiso, Y., Watanabe, T., Kaise, K., Kaise, N., Fukazawa, H., Yamamoto, M., Sakurada, T., Yoshinaga, K. J. Clin. Endocrinol. Metab. (1990) [Pubmed]
  23. Reduced binding and antilipolytic effect of prostaglandin E2 in adipocytes from patients with hyperthyroidism. Richelsen, B., Pedersen, O., Sørensen, N.S. J. Clin. Endocrinol. Metab. (1986) [Pubmed]
  24. Remission of Graves' hyperthyroidism and A/G polymorphism at position 49 in exon 1 of cytotoxic T lymphocyte-associated molecule-4 gene. Kinjo, Y., Takasu, N., Komiya, I., Tomoyose, T., Takara, M., Kouki, T., Shimajiri, Y., Yabiku, K., Yoshimura, H. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  25. Unaltered lymphocyte beta-adrenoceptor responsiveness in hyperthyroidism and hypothyroidism. Smith, B.M., Silas, J.H., Yates, R.O. Clin. Pharmacol. Ther. (1981) [Pubmed]
  26. Alteration in intracellular sodium concentration and ouabain-sensitive ATPase in erythrocytes from hyperthyroid patients. Cole, C.H., Waddell, R.W. J. Clin. Endocrinol. Metab. (1976) [Pubmed]
  27. Severe congenital hyperthyroidism caused by a germ-line neo mutation in the extracellular portion of the thyrotropin receptor. Grüters, A., Schöneberg, T., Biebermann, H., Krude, H., Krohn, H.P., Dralle, H., Gudermann, T. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  28. Juvenile hyperthyroidism with elevated thyrotropin (TSH) and normal 24 hour FSH, LH, GH and prolactin secretory patterns. Novogroder, M., Utiger, R., Boyar, R., Levine, L.S. J. Clin. Endocrinol. Metab. (1977) [Pubmed]
  29. Different growth hormone (GH) response to GH-releasing peptide and GH-releasing hormone in hyperthyroidism. Ramos-Dias, J.C., Pimentel-Filho, F., Reis, A.F., Lengyel, A.M. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
  30. Effect of thyroid dysfunction on high-density lipoprotein subfraction metabolism: roles of hepatic lipase and cholesteryl ester transfer protein. Tan, K.C., Shiu, S.W., Kung, A.W. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  31. Differential requirement of signal transducer and activator of transcription-4 (Stat4) and Stat6 in a thyrotropin receptor-289-adenovirus-induced model of Graves' hyperthyroidism. Land, K.J., Gudapati, P., Kaplan, M.H., Seetharamaiah, G.S. Endocrinology (2006) [Pubmed]
  32. Preparation of 125-I-labeled human thyroxine-binding alpha globulin and its turnover in normal and hypothyroid subjects. Cavalieri, R.R., McMahon, F.A., Castle, J.N. J. Clin. Invest. (1975) [Pubmed]
  33. The effect of thyroid hormone on skeletal integrity. Greenspan, S.L., Greenspan, F.S. Ann. Intern. Med. (1999) [Pubmed]
  34. A novel murine model of Graves' hyperthyroidism with intramuscular injection of adenovirus expressing the thyrotropin receptor. Nagayama, Y., Kita-Furuyama, M., Ando, T., Nakao, K., Mizuguchi, H., Hayakawa, T., Eguchi, K., Niwa, M. J. Immunol. (2002) [Pubmed]
  35. Propranolol and thyroidectomy in the treatment of thyrotoxicosis. Lee, T.C., Coffey, R.J., Currier, B.M., Ma, X.P., Canary, J.J. Ann. Surg. (1982) [Pubmed]
  36. Serum antibodies against the flavoprotein subunit of succinate dehydrogenase are sensitive markers of eye muscle autoimmunity in patients with Graves' hyperthyroidism. Gunji, K., De Bellis, A., Kubota, S., Swanson, J., Wengrowicz, S., Cochran, B., Ackrell, B.A., Salvi, M., Bellastella, A., Bizzarro, A., Sinisi, A.A., Wall, J.R. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
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