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Gene Review:

CASP3 - caspase 3, apoptosis-related cysteine...

Felis catus

Yamazaki, J. et al., Cahuana, G.M. et al., Natoni, A. et al., Best, S.M. et al.

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High impact information on CASP3

Release of cytochrome c from mitochondria triggered the activation of caspase-9 and the subsequent activation of the executioner caspase, caspase-3 [1].
Inhibitors of advanced lipooxidation end products (ALEs) formation such as aminoguanidine (AG) and pyridoxamine (PM) prevented partially apoptotic events triggered by NO such as DNA fragmentation, caspase-3 activation and cytochrome c release from mitochondria [2].
Pretreatment of infected cells with caspase 3 or broad-spectrum caspase inhibitors prevented apoptosis [3].
The full length cDNA sequence of bax (646 bp), bcl-2 (1423 bp), bcl-xL (1163 bp) and caspase 3 genes (1208 bp) contained a single open reading frame of 579 bp coding 193 amino acids, 708 bp coding 236 amino acids, 702 bp coding 234 amino acids and 834 bp coding 278 amino acids, respectively [4].
In the present study, full length of feline bax, bcl-2, bcl-xL and caspase 3 genes were sequenced and the expression of these mRNAs were also investigated in FIV-infected lymphocytes [4].

References

The mitochondrial pathway of apoptosis is triggered during feline calicivirus infection. Natoni, A., Kass, G.E., Carter, M.J., Roberts, L.O. J. Gen. Virol. (2006) [Pubmed]
Involvement of advanced lipooxidation end products (ALEs) and protein oxidation in the apoptotic actions of nitric oxide in insulin secreting RINm5F cells. Cahuana, G.M., Tejedo, J.R., Jiménez, J., Ramírez, R., Sobrino, F., Bedoya, F.J. Biochem. Pharmacol. (2003) [Pubmed]
Caspase activation is required for permissive replication of Aleutian mink disease parvovirus in vitro. Best, S.M., Wolfinbarger, J.B., Bloom, M.E. Virology (2002) [Pubmed]
Expression of apoptosis-related gene mRNAs in feline T-cells infected with feline immunodeficiency virus (FIV). Yamazaki, J., Hasebe, N., Nagafuchi, S., Baba, K., Tsujimoto, H., Kano, R., Hasegawa, A. Vet. Microbiol. (2004) [Pubmed]

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