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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

DNA Fragmentation

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Disease relevance of DNA Fragmentation


High impact information on DNA Fragmentation


Chemical compound and disease context of DNA Fragmentation


Biological context of DNA Fragmentation


Anatomical context of DNA Fragmentation


Associations of DNA Fragmentation with chemical compounds

  • Both the Ca2+ increase and DNA fragmentation were prevented in cells treated with the inhibitor of protein synthesis, cycloheximide, and DNA fragmentation and cell killing were not detected when cells were incubated in a "Ca2+-free" medium or pretreated with high concentrations of the calcium probe, quin-2 tetraacetoxymethyl ester [26].
  • The effects of C2-ceramide on DNA fragmentation were prevented by the protein kinase C activator phorbol 12-myristate 13-acetate, which suggests the existence of two opposing intracellular pathways in the regulation of apoptosis [27].
  • Induction of DNA fragmentation required the cytoplasmic domain of the mutants and appeared to be mediated by heterotrimeric guanosine triphosphate-binding proteins (G proteins) [28].
  • Inhibition of DNA fragmentation required substantially higher levels of caspase-3 attenuation than that required for blockade of other apoptotic events such as spectrin proteolysis and phosphatidylserine externalization [29].
  • Biochemical pathways of apoptosis: nicotinamide adenine dinucleotide-deficient cells are resistant to tumor necrosis factor or ultraviolet light activation of the 24-kD apoptotic protease and DNA fragmentation [23].

Gene context of DNA Fragmentation


Analytical, diagnostic and therapeutic context of DNA Fragmentation


  1. Interleukin 3 prevents delayed neuronal death in the hippocampal CA1 field. Wen, T.C., Tanaka, J., Peng, H., Desaki, J., Matsuda, S., Maeda, N., Fujita, H., Sato, K., Sakanaka, M. J. Exp. Med. (1998) [Pubmed]
  2. Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. Chang, G.Q., Hao, Y., Wong, F. Neuron (1993) [Pubmed]
  3. High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells. Bhalla, K., Ibrado, A.M., Tourkina, E., Tang, C., Grant, S., Bullock, G., Huang, Y., Ponnathpur, V., Mahoney, M.E. Blood (1993) [Pubmed]
  4. Hypoxia-induced cell death in human malignant glioma cells: energy deprivation promotes decoupling of mitochondrial cytochrome c release from caspase processing and necrotic cell death. Steinbach, J.P., Wolburg, H., Klumpp, A., Probst, H., Weller, M. Cell Death Differ. (2003) [Pubmed]
  5. Teratogen-induced cell death in postimplantation mouse embryos: differential tissue sensitivity and hallmarks of apoptosis. Mirkes, P.E., Little, S.A. Cell Death Differ. (1998) [Pubmed]
  6. Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability. Li, X., Manley, J.L. Cell (2005) [Pubmed]
  7. Cidea-deficient mice have lean phenotype and are resistant to obesity. Zhou, Z., Yon Toh, S., Chen, Z., Guo, K., Ng, C.P., Ponniah, S., Lin, S.C., Hong, W., Li, P. Nat. Genet. (2003) [Pubmed]
  8. Apoptosis in myocytes in end-stage heart failure. Narula, J., Haider, N., Virmani, R., DiSalvo, T.G., Kolodgie, F.D., Hajjar, R.J., Schmidt, U., Semigran, M.J., Dec, G.W., Khaw, B.A. N. Engl. J. Med. (1996) [Pubmed]
  9. A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells. Tian, Q., Streuli, M., Saito, H., Schlossman, S.F., Anderson, P. Cell (1991) [Pubmed]
  10. Endonuclease G is an apoptotic DNase when released from mitochondria. Li, L.Y., Luo, X., Wang, X. Nature (2001) [Pubmed]
  11. Induction of internucleosomal DNA fragmentation in human myeloid leukemia cells by 1-beta-D-arabinofuranosylcytosine. Gunji, H., Kharbanda, S., Kufe, D. Cancer Res. (1991) [Pubmed]
  12. Mycobacterium tuberculosis promotes apoptosis in human neutrophils by activating caspase-3 and altering expression of Bax/Bcl-xL via an oxygen-dependent pathway. Perskvist, N., Long, M., Stendahl, O., Zheng, L. J. Immunol. (2002) [Pubmed]
  13. Involvement of oxidative stress in tumor cytotoxic activity of hepatocyte growth factor/scatter factor. Arakaki, N., Kajihara, T., Arakaki, R., Ohnishi, T., Kazi, J.A., Nakashima, H., Daikuhara, Y. J. Biol. Chem. (1999) [Pubmed]
  14. Hypoxia sensitizes cells to nitric oxide-induced apoptosis. Lee, V.Y., McClintock, D.S., Santore, M.T., Budinger, G.R., Chandel, N.S. J. Biol. Chem. (2002) [Pubmed]
  15. Glutathione depletion induces apoptosis of rat hepatocytes through activation of protein kinase C novel isoforms and dependent increase in AP-1 nuclear binding. Domenicotti, C., Paola, D., Vitali, A., Nitti, M., d'Abramo, C., Cottalasso, D., Maloberti, G., Biasi, F., Poli, G., Chiarpotto, E., Marinari, U.M., Pronzato, M.A. Free Radic. Biol. Med. (2000) [Pubmed]
  16. Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate. Cuvillier, O., Pirianov, G., Kleuser, B., Vanek, P.G., Coso, O.A., Gutkind, S., Spiegel, S. Nature (1996) [Pubmed]
  17. Loss of splicing factor ASF/SF2 induces G2 cell cycle arrest and apoptosis, but inhibits internucleosomal DNA fragmentation. Li, X., Wang, J., Manley, J.L. Genes Dev. (2005) [Pubmed]
  18. Reactive oxygen species regulate activation-induced T cell apoptosis. Hildeman, D.A., Mitchell, T., Teague, T.K., Henson, P., Day, B.J., Kappler, J., Marrack, P.C. Immunity (1999) [Pubmed]
  19. Separate metabolic pathways leading to DNA fragmentation and apoptotic chromatin condensation. Sun, D.Y., Jiang, S., Zheng, L.M., Ojcius, D.M., Young, J.D. J. Exp. Med. (1994) [Pubmed]
  20. Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression. Dancescu, M., Rubio-Trujillo, M., Biron, G., Bron, D., Delespesse, G., Sarfati, M. J. Exp. Med. (1992) [Pubmed]
  21. Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways. Moley, K.H., Chi, M.M., Knudson, C.M., Korsmeyer, S.J., Mueckler, M.M. Nat. Med. (1998) [Pubmed]
  22. Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo. Zamzami, N., Marchetti, P., Castedo, M., Zanin, C., Vayssière, J.L., Petit, P.X., Kroemer, G. J. Exp. Med. (1995) [Pubmed]
  23. Biochemical pathways of apoptosis: nicotinamide adenine dinucleotide-deficient cells are resistant to tumor necrosis factor or ultraviolet light activation of the 24-kD apoptotic protease and DNA fragmentation. Wright, S.C., Wei, Q.S., Kinder, D.H., Larrick, J.W. J. Exp. Med. (1996) [Pubmed]
  24. Calcium ion concentrations and DNA fragmentation in target cell destruction by murine cloned cytotoxic T lymphocytes. Allbritton, N.L., Verret, C.R., Wolley, R.C., Eisen, H.N. J. Exp. Med. (1988) [Pubmed]
  25. Mechanism of interferon beta-induced squamous differentiation and programmed cell death in human non-small-cell lung cancer cell lines. Lokshin, A., Mayotte, J.E., Levitt, M.L. J. Natl. Cancer Inst. (1995) [Pubmed]
  26. 2,3,7,8-Tetrachlorodibenzo-p-dioxin kills immature thymocytes by Ca2+-mediated endonuclease activation. McConkey, D.J., Hartzell, P., Duddy, S.K., Håkansson, H., Orrenius, S. Science (1988) [Pubmed]
  27. Programmed cell death induced by ceramide. Obeid, L.M., Linardic, C.M., Karolak, L.A., Hannun, Y.A. Science (1993) [Pubmed]
  28. G protein-mediated neuronal DNA fragmentation induced by familial Alzheimer's disease-associated mutants of APP. Yamatsuji, T., Matsui, T., Okamoto, T., Komatsuzaki, K., Takeda, S., Fukumoto, H., Iwatsubo, T., Suzuki, N., Asami-Odaka, A., Ireland, S., Kinane, T.B., Giambarella, U., Nishimoto, I. Science (1996) [Pubmed]
  29. Differential efficacy of caspase inhibitors on apoptosis markers during sepsis in rats and implication for fractional inhibition requirements for therapeutics. Méthot, N., Huang, J., Coulombe, N., Vaillancourt, J.P., Rasper, D., Tam, J., Han, Y., Colucci, J., Zamboni, R., Xanthoudakis, S., Toulmond, S., Nicholson, D.W., Roy, S. J. Exp. Med. (2004) [Pubmed]
  30. Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradation. Mukae, N., Yokoyama, H., Yokokura, T., Sakoyama, Y., Nagata, S. Genes Dev. (2002) [Pubmed]
  31. Nucleophosmin/B23, a nuclear PI(3,4,5)P(3) receptor, mediates the antiapoptotic actions of NGF by inhibiting CAD. Ahn, J.Y., Liu, X., Cheng, D., Peng, J., Chan, P.K., Wade, P.A., Ye, K. Mol. Cell (2005) [Pubmed]
  32. Two distinct pathways leading to nuclear apoptosis. Susin, S.A., Daugas, E., Ravagnan, L., Samejima, K., Zamzami, N., Loeffler, M., Costantini, P., Ferri, K.F., Irinopoulou, T., Prévost, M.C., Brothers, G., Mak, T.W., Penninger, J., Earnshaw, W.C., Kroemer, G. J. Exp. Med. (2000) [Pubmed]
  33. Contrasting nuclear dynamics of the caspase-activated DNase (CAD) in dividing and apoptotic cells. Lechardeur, D., Xu, M., Lukacs, G.L. J. Cell Biol. (2004) [Pubmed]
  34. Distinct protein kinase C isozymes signal mitogenesis and apoptosis in human colon cancer cells. Weller, S.G., Klein, I.K., Penington, R.C., Karnes, W.E. Gastroenterology (1999) [Pubmed]
  35. Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa. Portera-Cailliau, C., Sung, C.H., Nathans, J., Adler, R. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  36. 3-Hydroxy-3-methylglutaryl coenzyme a reductase and isoprenylation inhibitors induce apoptosis of vascular smooth muscle cells in culture. Guijarro, C., Blanco-Colio, L.M., Ortego, M., Alonso, C., Ortiz, A., Plaza, J.J., Díaz, C., Hernández, G., Egido, J. Circ. Res. (1998) [Pubmed]
  37. Comparison of caspase activation and subcellular localization in HL-60 and K562 cells undergoing etoposide-induced apoptosis. Martins, L.M., Mesner, P.W., Kottke, T.J., Basi, G.S., Sinha, S., Tung, J.S., Svingen, P.A., Madden, B.J., Takahashi, A., McCormick, D.J., Earnshaw, W.C., Kaufmann, S.H. Blood (1997) [Pubmed]
  38. Alterations in the post-translational modification and intracellular trafficking of clusterin in MCF-7 cells during apoptosis. O'Sullivan, J., Whyte, L., Drake, J., Tenniswood, M. Cell Death Differ. (2003) [Pubmed]
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