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OAZ2  -  ornithine decarboxylase antizyme 2

Homo sapiens

Synonyms: AZ2, ODC-Az 2, Ornithine decarboxylase antizyme 2
 
 
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High impact information on OAZ2

  • AZ1 binds to ODC with about a 3-fold higher potency than AZ2, but this cannot account for their distinct degradative activities [1].
  • Ornithine decarboxylase antizyme 1 and 2 (OAZ1 and OAZ2) are expressed ubiquitously, and control the intracellular concentration of polyamines [2].
  • The objective of the present work was to study the luteinizing hormone (LH) pulsatility in OAZ-1 compared with both OAZ-2 and men of proven fertility (PF), in order partly to determine the possible aetiology of the blunted acute testosterone response to HCG in these patients [3].
 

Associations of OAZ2 with chemical compounds

  • In a previous study, we demonstrated that oligoasthenozoospermic (OAZ) patients had two types of testosterone response to human chorionic gonadotrophin (HCG) administration: group 1 (OAZ-1) had an altered, monophasic (no first peak) response, and group 2 (OAZ-2) had a normal biphasic response [3].

References

  1. Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase. Chen, H., MacDonald, A., Coffino, P. J. Biol. Chem. (2002) [Pubmed]
  2. Structure and promoter activity of the gene encoding ornithine decarboxylase antizyme expressed exclusively in haploid germ cells in testis (OAZt/Oaz3). Ike, A., Yamada, S., Tanaka, H., Nishimune, Y., Nozaki, M. Gene (2002) [Pubmed]
  3. Altered luteinizing hormone pulsatility in infertile patients with idiopathic oligoasthenozoospermia. Scaglia, H.E., Timossi, C.M., Carrere, C.A., Zylbersztein, C., Colombani, M.E., Rey-Valzacchi, G., Aquilano, D.R. Hum. Reprod. (1998) [Pubmed]
 
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