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Gene Review

ODC1  -  ornithine decarboxylase 1

Homo sapiens

Synonyms: ODC, Ornithine decarboxylase
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Disease relevance of ODC1


Psychiatry related information on ODC1


High impact information on ODC1


Chemical compound and disease context of ODC1


Biological context of ODC1


Anatomical context of ODC1


Associations of ODC1 with chemical compounds


Physical interactions of ODC1

  • In the present study, we show by yeast two- and three-hybrid protein-protein interaction studies that AZI interacts with all members of the antizyme family and is capable of disrupting the interaction between each antizyme and ODC [21].
  • UVB radiation induces phosphorylation of the epidermal growth factor receptor, decreases EGF binding and blocks EGF induction of ornithine decarboxylase gene expression in SV40-transformed human keratinocytes [22].

Regulatory relationships of ODC1


Other interactions of ODC1

  • Accumulation of PNT1A cells in the S phase progressively increased at 15, 18 and 24 h of transfection with antisense ODC and/or OAZ cDNA [27].
  • ODC-p has a unique mutation in cysteine 360, where this ornithine decarboxylase reaction-directing residue is substituted by a valine [28].
  • METHODS: PPARgamma, ODC and SSAT mRNA levels were evaluated by reverse transcriptase and real-time PCR [29].
  • As proof of concept, the ODC/AZ system was used to ablate expression of specific endogenous proteins (e.g., TRAF6; Rb), and was shown to create the expected lesions in cellular pathways that require these proteins [30].
  • AZ1 binds to ODC with about a 3-fold higher potency than AZ2, but this cannot account for their distinct degradative activities [31].

Analytical, diagnostic and therapeutic context of ODC1

  • The first is the previously described soluble pool, and the second is enriched in phospho-ODC and associated with insoluble cellular material that by immunohistochemistry appears to be organized in conjunction with the keratin cytoskeleton [32].
  • Fractionation and ODC immunoprecipitation from [(32)P]orthophosphate-labeled NHEK lysates showed that a phosphorylated form of ODC was present in the insoluble fractions [32].
  • Confocal immunofluorescence showed that ODC distribution in NHEK was primarily perinuclear; upon disruption of the actin cytoskeleton with cytochalasin D, ODC distribution was diffuse [32].
  • The partial cDNA sequence is 86% homologous to the mouse ODC cDNA, and Northern blots indicate that the human and mouse mRNA species are similar in size [33].
  • ODC mRNA was elevated 5-fold in MDA-MB-231 cells versus MCF-7 cells when analyzed in cell culture [34].


  1. Amplification of N-myc and ornithine decarboxylase genes in human neuroblastoma and hydroxyurea-resistant hamster cell lines. Tonin, P.N., Yeger, H., Stallings, R.L., Srinivasan, P.R., Lewis, W.H. Oncogene (1989) [Pubmed]
  2. Loss of methylthioadenosine phosphorylase and elevated ornithine decarboxylase is common in pancreatic cancer. Subhi, A.L., Tang, B., Balsara, B.R., Altomare, D.A., Testa, J.R., Cooper, H.S., Hoffman, J.P., Meropol, N.J., Kruger, W.D. Clin. Cancer Res. (2004) [Pubmed]
  3. Polyamine depletion by ODC-AdoMetDC antisense adenovirus impairs human colorectal cancer growth and invasion in vitro and in vivo. Zhang, B., Liu, X.X., Zhang, Y., Jiang, C.Y., Hu, H.Y., Gong, L., Liu, M., Teng, Q.S. The journal of gene medicine. (2006) [Pubmed]
  4. Ornithine decarboxylase G316A genotype is prognostic for colorectal adenoma recurrence and predicts efficacy of aspirin chemoprevention. Hubner, R.A., Muir, K.R., Liu, J.F., Logan, R.F., Grainge, M.J., Houlston, R.S. Clin. Cancer Res. (2008) [Pubmed]
  5. Altered subcellular localization of ornithine decarboxylase in Alzheimer's disease brain. Nilsson, T., Bogdanovic, N., Volkman, I., Winblad, B., Folkesson, R., Benedikz, E. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  6. Ornithine decarboxylase as a biologic marker in familial colonic polyposis. Luk, G.D., Baylin, S.B. N. Engl. J. Med. (1984) [Pubmed]
  7. Induction of ornithine decarboxylase by nerve growth factor dissociated from effects on survival and neurite outgrowth. Greene, L.A., McGuire, J.C. Nature (1978) [Pubmed]
  8. Ornithine decarboxylase: essential in proliferation but not differentiation of human promyelocytic leukemia cells. Luk, G.D., Civin, C.I., Weissman, R.M., Baylin, S.B. Science (1982) [Pubmed]
  9. Development of resistance to hydroxyurea during treatment of human myelogenous leukemia K562 cells with alpha-difluoromethylornithine as a result of coamplification of genes for ornithine decarboxylase and ribonucleotide reductase R2 subunit. Ask, A., Persson, L., Rehnholm, A., Frostesjö, L., Holm, I., Heby, O. Cancer Res. (1993) [Pubmed]
  10. Elevated expression of the ornithine decarboxylase gene in human esophageal cancer. Yoshida, M., Hayashi, H., Taira, M., Isono, K. Cancer Res. (1992) [Pubmed]
  11. Differential activation of ornithine decarboxylase and tyrosine kinase in the rectal mucosa of patients with hyperplastic and adenomatous polyps. Colarian, J., Arlow, F.L., Calzada, R., Luk, G.D., Majumdar, A.P. Gastroenterology (1991) [Pubmed]
  12. Prostanoids, ornithine decarboxylase, and polyamines in primary chemoprevention of familial adenomatous polyposis. Giardiello, F.M., Casero, R.A., Hamilton, S.R., Hylind, L.M., Trimbath, J.D., Geiman, D.E., Judge, K.R., Hubbard, W., Offerhaus, G.J., Yang, V.W. Gastroenterology (2004) [Pubmed]
  13. Platinum drug effects on the expression of genes in the polyamine pathway: time-course and concentration-effect analysis based on Affymetrix gene expression profiling of A2780 ovarian carcinoma cells. Varma, R., Hector, S., Greco, W.R., Clark, K., Hawthorn, L., Porter, C., Pendyala, L. Cancer Chemother. Pharmacol. (2007) [Pubmed]
  14. Antibody-bound amyloid precursor protein upregulates ornithine decarboxylase expression. Nilsson, T., Malkiewicz, K., Gabrielsson, M., Folkesson, R., Winblad, B., Benedikz, E. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
  15. Adenovirus-mediated Expression of Both Antisense Ornithine Decarboxylase and S-adenosylmethionine Decarboxylase Induces G(1) Arrest in HT-29 Cells. Gong, L., Jiang, C., Zhang, B., Hu, H., Wang, W., Liu, X. J. Biochem. Mol. Biol. (2006) [Pubmed]
  16. Human ornithine decarboxylase sequences map to chromosome regions 2pter----p23 and 7cen----qter but are not coamplified with the NMYC oncogene. Winqvist, R., Mäkelä, T.P., Seppänen, P., Jänne, O.A., Alhonen-Hongisto, L., Jänne, J., Grzeschik, K.H., Alitalo, K. Cytogenet. Cell Genet. (1986) [Pubmed]
  17. Polyamine metabolism and cell-cycle-dependent gene expression in IMR-90 human diploid fibroblasts during senescence in culture. Chen, K.Y., Chang, Z.F., Pang, J.H., He, G.S., Liu, A.Y. Exp. Gerontol. (1989) [Pubmed]
  18. Potentiation of apple procyanidin-triggered apoptosis by the polyamine oxidase inactivator MDL 72527 in human colon cancer-derived metastatic cells. Gossé, F., Roussi, S., Guyot, S., Schoenfelder, A., Mann, A., Bergerat, J.P., Seiler, N., Raul, F. Int. J. Oncol. (2006) [Pubmed]
  19. Mouse Ornithine Decarboxylase-like Gene Encodes an Antizyme Inhibitor Devoid of Ornithine and Arginine Decarboxylating Activity. L??pez-Contreras, A.J., L??pez-Garcia, C., Jim??nez-Cervantes, C., Cremades, A., Pe??afiel, R. J. Biol. Chem. (2006) [Pubmed]
  20. Nitric oxide inhibits ornithine decarboxylase via S-nitrosylation of cysteine 360 in the active site of the enzyme. Bauer, P.M., Buga, G.M., Fukuto, J.M., Pegg, A.E., Ignarro, L.J. J. Biol. Chem. (2001) [Pubmed]
  21. Regulation of all members of the antizyme family by antizyme inhibitor. Mangold, U., Leberer, E. Biochem. J. (2005) [Pubmed]
  22. UVB radiation induces phosphorylation of the epidermal growth factor receptor, decreases EGF binding and blocks EGF induction of ornithine decarboxylase gene expression in SV40-transformed human keratinocytes. Zheng, Z.S., Chen, R.Z., Prystowsky, J.H. Exp. Dermatol. (1993) [Pubmed]
  23. Stable siRNA-mediated silencing of antizyme inhibitor: regulation of ornithine decarboxylase activity. Choi, K.S., Suh, Y.H., Kim, W.H., Lee, T.H., Jung, M.H. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  24. The MYCN oncoprotein as a drug development target. Lu, X., Pearson, A., Lunec, J. Cancer Lett. (2003) [Pubmed]
  25. Human ornithine decarboxylase-encoding loci: nucleotide sequence of the expressed gene and characterization of a pseudogene. Hickok, N.J., Wahlfors, J., Crozat, A., Halmekytö, M., Alhonen, L., Jänne, J., Jänne, O.A. Gene (1990) [Pubmed]
  26. Prolactin, immunoregulation, and autoimmune diseases. Jara, L.J., Lavalle, C., Fraga, A., Gómez-Sanchez, C., Silveira, L.H., Martínez-Osuna, P., Germain, B.F., Espinoza, L.R. Semin. Arthritis Rheum. (1991) [Pubmed]
  27. Manipulation of the expression of regulatory genes of polyamine metabolism results in specific alterations of the cell-cycle progression. Scorcioni, F., Corti, A., Davalli, P., Astancolle, S., Bettuzzi, S. Biochem. J. (2001) [Pubmed]
  28. Expression of a novel human ornithine decarboxylase-like protein in the central nervous system and testes. Pitkänen, L.T., Heiskala, M., Andersson, L.C. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  29. Peroxisome proliferator-activated receptor gamma and spermidine/spermine N1-acetyltransferase gene expressions are significantly correlated in human colorectal cancer. Linsalata, M., Giannini, R., Notarnicola, M., Cavallini, A. BMC Cancer (2006) [Pubmed]
  30. Method for targeting protein destruction by using a ubiquitin-independent, proteasome-mediated degradation pathway. Matsuzawa, S., Cuddy, M., Fukushima, T., Reed, J.C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  31. Structural elements of antizymes 1 and 2 are required for proteasomal degradation of ornithine decarboxylase. Chen, H., MacDonald, A., Coffino, P. J. Biol. Chem. (2002) [Pubmed]
  32. Phosphorylated human keratinocyte ornithine decarboxylase is preferentially associated with insoluble cellular proteins. Pomidor, M.M., Cimildoro, R., Lazatin, B., Zheng, P., Gurr, J.A., Leigh, I.M., Jänne, O.A., Tuan, R.S., Hickok, N.J. Mol. Biol. Cell (1999) [Pubmed]
  33. Cell-cycle-dependent expression of human ornithine decarboxylase. Kaczmarek, L., Calabretta, B., Ferrari, S., de Riel, J.K. J. Cell. Physiol. (1987) [Pubmed]
  34. Regulation of ornithine decarboxylase mRNA levels in human breast cancer cells: pattern of expression and involvement of core enhancer promoter element. Wright, P.S., Cooper, J.R., Cross-Doersen, D.E., Miller, J.A., Chmielewski, P.A., Wagner, R.L., Streng, K.A., Flanagan, M.A. Cell Growth Differ. (1995) [Pubmed]
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