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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CCR5  -  chemokine (C-C motif) receptor 5

Bos taurus

 
 
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Disease relevance of CCR5

  • Collectively, these data provide preliminary evidence that BIV may utilize the CCR5 receptor for infection of cells in vitro, but additional studies are necessary to confirm this [1].
  • The results of this study help to explain the structural basis for the recognition, activation, and inhibition processes of CCR5 and may provide fresh insights for the design of HIV-1 entry blockers [2].
 

High impact information on CCR5

  • Transcript analysis showed that antigen stimulation of WC1(+)gammadelta T cells induced IFN-gamma production and substantially increased CCR5 and CXCR3 expression when compared with freshly isolated (ex vivo) cells [3].

References

  1. Bovine immunodeficiency virus expression in vitro is reduced in the presence of beta-chemokines, MIP-1alpha, MIP-1beta and RANTES. Wright, S.M., Mleczko, A., Coats, K.S. Vet. Res. Commun. (2002) [Pubmed]
  2. Modeling the structural basis of human CCR5 chemokine receptor function: from homology model building and molecular dynamics validation to agonist and antagonist docking. Fano, A., Ritchie, D.W., Carrieri, A. Journal of chemical information and modeling. (2006) [Pubmed]
  3. Molecular cloning of bovine chemokine receptors and expression by WC1+ gammadelta T cells. Blumerman, S.L., Wang, F., Herzig, C.T., Baldwin, C.L. Dev. Comp. Immunol. (2007) [Pubmed]
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