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MeSH Review

Immunodeficiency Virus, Bovine

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Disease relevance of Immunodeficiency Virus, Bovine


Psychiatry related information on Immunodeficiency Virus, Bovine


High impact information on Immunodeficiency Virus, Bovine

  • The Tat protein of bovine immunodeficiency virus (BIV) binds to its target RNA, TAR, and activates transcription [7].
  • A 14-amino acid arginine-rich peptide corresponding to the RNA-binding domain of BIV Tat binds specifically to BIV TAR, and biochemical and in vivo experiments have identified the amino acids and nucleotides required for binding [7].
  • The arginine-rich RNA-binding domain of bovine immunodeficiency virus (BIV) Tat adopts a beta-hairpin conformation upon binding to the major groove of BIV TAR [8].
  • DNase I footprinting analysis and electrophoretic mobility shift assays showed that oligonucleotide probes corresponding to three regions, -1171 to -1142 (BI), -1136 to -1111 (BII), and -783 to -751 (BIV), bound proteins in U937 nuclear extracts [9].
  • Structures considered are the three different tRNA synthetase complexes, the U1A spliceosomal protein with an RNA hairpin and the BIV TAR-Tat complex [10].

Chemical compound and disease context of Immunodeficiency Virus, Bovine


Biological context of Immunodeficiency Virus, Bovine


Anatomical context of Immunodeficiency Virus, Bovine


Gene context of Immunodeficiency Virus, Bovine

  • BIV inhibited RNA function more potently than CIV and this was not dependent on TS or DPD activity [25].
  • DPD activity and TS activity were not significantly different between the CIV and the BIV groups in the tumor and non-tumor region, respectively [25].
  • In functional studies, the expression of BIV Rev was shown to positively regulate the appearance both of Gag protein, which is translated from the unspliced primary viral transcript, and of singly spliced env mRNA but not that of the multiply spliced tat mRNA [4].
  • To further analyze the BIV rev gene locus, protein, and function, rev cDNAs were cloned and characterized [4].
  • In the related bovine immunodeficiency virus (BIV), Tat recognizes its cognate TAR element with high affinity and specificity in the absence of CycT1 [26].

Analytical, diagnostic and therapeutic context of Immunodeficiency Virus, Bovine

  • We examined sera from laboratory personnel at risk for BIV exposure, including two laboratory workers who were exposed to BIV by accidental injection with BIV-infected cell culture material, and found no evidence of seroconversion to BIV-specific proteins [27].
  • Traditionally, IL-2 has been administered by three different routes: intermittent bolus injection (BIV), continuous intravenous infusion (CIV) and subcutaneous injection (SC) [28].
  • Microinjection of purified DNA from BIV clone 106 or 127 into susceptible bovine cells produces virus-specific cytopathic effects, including syncytium induction, supernatant reverse transcriptase activity, and infectious virus particle formation, similar to the effects produced by parental virus stock [29].
  • Both 104 and 142 antibodies were isotyped as IgG1; they reacted specifically with both BIV p26 and the recombinant fusion protein in Western immunoblot analyses [30].
  • By 4 weeks postinoculation (p.i.), antibodies reactive to BIV gag- and env-encoded recombinant fusion proteins were detectable by immunoblotting in all animals [31].


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  4. Characterization of bovine immunodeficiency virus rev cDNAs and identification and subcellular localization of the Rev protein. Oberste, M.S., Williamson, J.C., Greenwood, J.D., Nagashima, K., Copeland, T.D., Gonda, M.A. J. Virol. (1993) [Pubmed]
  5. Replication of human immunodeficiency viruses engineered with heterologous Tat-transactivation response element interactions. Xie, B., Wainberg, M.A., Frankel, A.D. J. Virol. (2003) [Pubmed]
  6. Increased beclomethasone-induced vasoconstriction in women with posttraumatic stress disorder. Coupland, N.J., Hegadoren, K.M., Myrholm, J. Journal of psychiatric research. (2003) [Pubmed]
  7. Solution structure of a bovine immunodeficiency virus Tat-TAR peptide-RNA complex. Puglisi, J.D., Chen, L., Blanchard, S., Frankel, A.D. Science (1995) [Pubmed]
  8. Structure-based design of a dimeric RNA-peptide complex. Campisi, D.M., Calabro, V., Frankel, A.D. EMBO J. (2001) [Pubmed]
  9. Characterization of the promoter of human leukocyte-specific transcript 1. A small gene with a complex pattern of alternative transcripts. Yu, X., Weissman, S.M. J. Biol. Chem. (2000) [Pubmed]
  10. RNA base-amino acid interaction strengths derived from structures and sequences. Lustig, B., Arora, S., Jernigan, R.L. Nucleic Acids Res. (1997) [Pubmed]
  11. Identification and characterization of the bovine immunodeficiency-like virus tat gene. Liu, Z.Q., Sheridan, D., Wood, C. J. Virol. (1992) [Pubmed]
  12. Amino acid sequence analysis of the proteolytic cleavage products of the bovine immunodeficiency virus Gag precursor polypeptide. Tobin, G.J., Sowder, R.C., Fabris, D., Hu, M.Y., Battles, J.K., Fenselau, C., Henderson, L.E., Gonda, M.A. J. Virol. (1994) [Pubmed]
  13. Cis-acting sequences may contribute to size variation in the surface glycoprotein of bovine immunodeficiency virus. Li, Y., Carpenter, S. J. Gen. Virol. (2001) [Pubmed]
  14. Detection of proviral DNA of bovine immunodeficiency virus in bovine tissues by polymerase chain reaction (PCR) and PCR in situ hybridization. Zhang, S., Troyer, D.L., Kapil, S., Zheng, L., Kennedy, G., Weiss, M., Xue, W., Wood, C., Minocha, H.C. Virology (1997) [Pubmed]
  15. Beclomethasone-induced vasoconstriction in women with major depressive disorder. Coupland, N.J., Hegadoren, K.M., Myrholm, J. Journal of psychiatry & neuroscience : JPN. (2003) [Pubmed]
  16. Structural mimicry of retroviral tat proteins by constrained beta-hairpin peptidomimetics: ligands with high affinity and selectivity for viral TAR RNA regulatory elements. Athanassiou, Z., Dias, R.L., Moehle, K., Dobson, N., Varani, G., Robinson, J.A. J. Am. Chem. Soc. (2004) [Pubmed]
  17. Isolation and characterization of new wild-type isolates of bovine lentivirus. Suarez, D.L., VanDerMaaten, M.J., Wood, C., Whetstone, C.A. J. Virol. (1993) [Pubmed]
  18. Identification of transactivation-response sequences in the long terminal repeat of bovine immunodeficiency-like virus. Carpenter, S., Nadin-Davis, S.A., Wannemuehler, Y., Roth, J.A. J. Virol. (1993) [Pubmed]
  19. TAR RNA recognition by a cyclic peptidomimetic of Tat protein. Leeper, T.C., Athanassiou, Z., Dias, R.L., Robinson, J.A., Varani, G. Biochemistry (2005) [Pubmed]
  20. An RNA-binding peptide from bovine immunodeficiency virus Tat protein recognizes an unusual RNA structure. Chen, L., Frankel, A.D. Biochemistry (1994) [Pubmed]
  21. Activation of bovine immunodeficiency-like virus expression by bovine herpesvirus type 1. Geng, Y., Kashanchi, F., Wood, C. Virology (1992) [Pubmed]
  22. Tat protein expression in MDBK cells does not confer susceptibility to bovine immunodeficiency virus. Kempster, S., Collins, M.E., Brownlie, J. Arch. Virol. (2002) [Pubmed]
  23. Enhancement of monocyte migration and phagocytosis by the bovine immunodeficiency-like virus Gag proteins. Rovid, A.H., Roth, J.A. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. (1997) [Pubmed]
  24. Very low prevalence of bovine immunodeficiency virus infection in western Canadian cattle. Gonzalez, G.C., Johnston, J.B., Nickel, D.D., Jacobs, R.M., Olson, M., Power, C. Can. J. Vet. Res. (2001) [Pubmed]
  25. Differential effects of two fluorouracil administration regimens for colorectal cancer. Matsusaka, S., Yamasaki, H., Kitayama, Y., Okada, T., Maeda, S. Oncol. Rep. (2003) [Pubmed]
  26. Evidence for conformational flexibility in the Tat-TAR recognition motif of cyclin T1. Das, C., Edgcomb, S.P., Peteranderl, R., Chen, L., Frankel, A.D. Virology (2004) [Pubmed]
  27. Examination of whether persistently indeterminate human immunodeficiency virus type 1 Western immunoblot reactions are due to serological reactivity with bovine immunodeficiency-like virus. Whetstone, C.A., Sayre, K.R., Dock, N.L., VanDerMaaten, M.J., Miller, J.M., Lillehoj, E., Alexander, S.S. J. Clin. Microbiol. (1992) [Pubmed]
  28. A systematic review of the relation between interleukin-2 schedule and outcome in patients with metastatic renal cell cancer. Baaten, G., Voogd, A.C., Wagstaff, J. Eur. J. Cancer (2004) [Pubmed]
  29. Molecular cloning of biologically active proviruses of bovine immunodeficiency-like virus. Braun, M.J., Lahn, S., Boyd, A.L., Kost, T.A., Nagashima, K., Gonda, M.A. Virology (1988) [Pubmed]
  30. In vitro detection of bovine immunodeficiency-like virus using monoclonal antibodies generated to a recombinant gag fusion protein. Wannemuehler, Y., Isaacson, J., Wannemuehler, M., Wood, C., Roth, J.A., Carpenter, S. J. Virol. Methods (1993) [Pubmed]
  31. Loss of Gag-specific antibody reactivity in cattle experimentally infected with bovine immunodeficiency-like virus. Isaacson, J.A., Roth, J.A., Wood, C., Carpenter, S. Viral Immunol. (1995) [Pubmed]
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