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Gene Review: 

ADAMTS1  -  ADAM metallopeptidase with thrombospondin...

Sus scrofa

 
 
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High impact information on ADAMTS1

  • These results suggest that the expression and induction of ADAMTS-1 through receptor-mediated action of progesterone in cumulus cells is one of the essential requirements for gonadotropin-regulated cumulus expansion of porcine COCs [1].
  • In the present study, we investigated the time-dependent changes in ADAMTS-1 expression in cumulus cells of porcine cumulus-oocyte complexes (COCs), and the roles of ADAMTS-1 in cumulus expansion during in vitro maturation of oocytes [1].
  • The induction of ADAMTS-1 mRNA and protein was significantly decreased by the addition of PR antagonist RU486 to the cultures [1].
  • ADAMTS-1, a member of the A disintegrin and metalloproteinase family of proteases, is expressed in rodent follicles via progesterone receptor (PR)-dependent pathways [1].

References

  1. Down-regulated expression of A disintegrin and metalloproteinase with thrombospondin-like repeats-1 by progesterone receptor antagonist is associated with impaired expansion of porcine cumulus-oocyte complexes. Shimada, M., Nishibori, M., Yamashita, Y., Ito, J., Mori, T., Richards, J.S. Endocrinology (2004) [Pubmed]
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