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Chemical Compound Review

Mifegyne     (8S,11R,13S,14S,17S)-11-(4...

Synonyms: Mifeprex, mifepristone, RU-486, RU486, RU-38486, ...
 
 
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Disease relevance of Mifeprex

 

Psychiatry related information on Mifeprex

  • Mifepristone (RU 486) for Alzheimer's disease [7].
  • RU-486 also delayed the latency period but failed to reduce overall tumor incidence when animals were exposed to MPA at 6 weeks after DMBA treatment, indicating that other factors may also control MPA-induced acceleration [8].
  • RESULTS: Patients treated with mifepristone were significantly more likely to achieve response, defined as a 30% reduction in the Brief Psychiatric Rating Scale (BPRS) [9].
  • CONCLUSIONS: In contrast to our earlier report of positive effects in bipolar disorder, these data suggest that the GR-antagonist mifepristone has no effect on neurocognitive function or symptoms in this group of patients with schizophrenia [10].
  • CYP3A9 mRNA levels were highest in food-deprived animals, whereas RU486 inhibited CYP3A9 mRNA expression and suppressed the induction effect of food deprivation [11].
 

High impact information on Mifeprex

 

Chemical compound and disease context of Mifeprex

 

Biological context of Mifeprex

 

Anatomical context of Mifeprex

 

Associations of Mifeprex with other chemical compounds

 

Gene context of Mifeprex

 

Analytical, diagnostic and therapeutic context of Mifeprex

References

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  3. Successful mifepristone treatment of recurrent, inoperable meningioma. Haak, H.R., de Keizer, R.J., Hagenouw-Taal, J.C., van Seters, A.P., Vielvoye, G.J., van Dulken, H. Lancet (1990) [Pubmed]
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  5. Induction of labour with mifepristone after intrauterine fetal death. Cabrol, D., Bouvier D'Yvoire, M., Mermet, E., Cedard, L., Sureau, C., Baulieu, E.E. Lancet (1985) [Pubmed]
  6. Mifepristone inhibits ovarian cancer cell growth in vitro and in vivo. Goyeneche, A.A., Carón, R.W., Telleria, C.M. Clin. Cancer Res. (2007) [Pubmed]
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  8. Natural and synthetic progestins accelerate 7,12-dimethylbenz[a]anthracene-initiated mammary tumors and increase angiogenesis in Sprague-Dawley rats. Benakanakere, I., Besch-Williford, C., Schnell, J., Brandt, S., Ellersieck, M.R., Molinolo, A., Hyder, S.M. Clin. Cancer Res. (2006) [Pubmed]
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  22. Lack of effect of induced menses on symptoms in women with premenstrual syndrome. Schmidt, P.J., Nieman, L.K., Grover, G.N., Muller, K.L., Merriam, G.R., Rubinow, D.R. N. Engl. J. Med. (1991) [Pubmed]
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  27. Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy. Chaisson, M.L., Brooling, J.T., Ladiges, W., Tsai, S., Fausto, N. J. Clin. Invest. (2002) [Pubmed]
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  30. Effect of mifepristone on dilatation of the pregnant and non-pregnant cervix. Gupta, J.K., Johnson, N. Lancet (1990) [Pubmed]
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  32. A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1. Cronstein, B.N., Kimmel, S.C., Levin, R.I., Martiniuk, F., Weissmann, G. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
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  42. Antiglucocorticosteroid effects suggest why steroid hormone is required for receptors to bind DNA in vivo but not in vitro. Groyer, A., Schweizer-Groyer, G., Cadepond, F., Mariller, M., Baulieu, E.E. Nature (1987) [Pubmed]
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  44. Postcoital contraception with mifepristone. Glasier, A., Thong, K.J., Dewar, M., Mackie, M., Baird, D.T. Lancet (1991) [Pubmed]
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