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Gene Review

PAFAH2  -  platelet-activating factor acetylhydrolase...

Homo sapiens

Synonyms: HSD-PLA2, Platelet-activating factor acetylhydrolase 2, cytoplasmic, SD-PLA2, Serine-dependent phospholipase A2, hSD-PLA2
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High impact information on PAFAH2

  • Moreover, sequence comparison indicates the HSD-PLA2 probable active site triad positions are shared with LDL-PLA2 and a C. elegans homologue, suggesting that these sequences comprise members of a new enzyme family [1].
  • Although clearly structurally related with similar substrate specificities further work reported here shows HSD-PLA2 and LDL-PLA2 to be different with respect to chromosomal localization and tissue distribution [1].
  • Using expressed sequence tag (EST) homology screening, a new human serine dependent phospholipase A2 (HSD-PLA2) was identified that has 40% amino acid identity with human low density lipoprotein-associated phospholipase A2 (LDL-PLA2) [1].


  1. Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor. Rice, S.Q., Southan, C., Boyd, H.F., Terrett, J.A., MacPhee, C.H., Moores, K., Gloger, I.S., Tew, D.G. Biochem. J. (1998) [Pubmed]
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