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Gene Review:

ARHGEF3 - Rho guanine nucleotide exchange factor...

Homo sapiens

Synonyms: DKFZP434F2429, Exchange factor found in platelets and leukemic and neuronal tissues, GEF3, Rho guanine nucleotide exchange factor 3, STA3, ...

Thiesen, S. et al., Arthur, W.T. et al.

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Disease relevance of ARHGEF3

A database search combined with screening of a human neuronal teratocarcinoma library identified two novel RhoGEFs, ARHGEF3 and ARHGEF4 (HGMW-approved symbols) [1].

High impact information on ARHGEF3

XPLN protein is expressed in the brain, skeletal muscle, heart, kidney, platelets, and macrophage and neuronal cell lines [2].
FISH analysis of genomic clones mapped ARHGEF3 to 3p13-21 and ARHGEF4 to 2q22 [1].

References

Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22. Thiesen, S., Kübart, S., Ropers, H.H., Nothwang, H.G. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. Arthur, W.T., Ellerbroek, S.M., Der, C.J., Burridge, K., Wennerberg, K. J. Biol. Chem. (2002) [Pubmed]

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ARHGEF3	Bos taurus
arhgef3	Danio rerio
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arhgef3	Xenopus (Silurana) tropicalis

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