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Disease relevance of Teratocarcinoma


High impact information on Teratocarcinoma

  • It is likely that this represents the in vivo mechanism, as well, since extracts from L8 myoblasts specifically demethylate an alpha-actin gene, while extracts from F9 teratocarcinoma cells specifically demodify the Aprt CpG island [6].
  • The Ter mutation in laboratory mice is novel in that it acts codominantly to reduce germ cell numbers on many inbred strain backgrounds and to enhance dramatically inherited predisposition to spontaneous testicular teratocarcinomas in strain 129 inbred mice [7].
  • Cotransfection of c-jun and jun-B with or without c-fos into F9 teratocarcinoma cells results in decreased trans-activation of AP-1 compared with either gene alone [8].
  • Using F9 teratocarcinoma cells, which are unresponsive to cAMP, we initiated a series of transient expression experiments to establish a causal link between phosphorylation of CREB and trans-activation of cAMP-responsive genes [9].
  • Upon differentiation of mouse teratocarcinoma cell line F9 with retinoic acid and cAMP, the expression of both genes was drastically reduced, and in one instance was undetectable [10].

Chemical compound and disease context of Teratocarcinoma


Biological context of Teratocarcinoma


Anatomical context of Teratocarcinoma


Gene context of Teratocarcinoma


Analytical, diagnostic and therapeutic context of Teratocarcinoma


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  7. A mutation in the Ter gene causing increased susceptibility to testicular teratomas maps to mouse chromosome 18. Asada, Y., Varnum, D.S., Frankel, W.N., Nadeau, J.H. Nat. Genet. (1994) [Pubmed]
  8. jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun. Schütte, J., Viallet, J., Nau, M., Segal, S., Fedorko, J., Minna, J. Cell (1989) [Pubmed]
  9. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Gonzalez, G.A., Montminy, M.R. Cell (1989) [Pubmed]
  10. A multigene family encoding several "finger" structures is present and differentially active in mammalian genomes. Chowdhury, K., Deutsch, U., Gruss, P. Cell (1987) [Pubmed]
  11. The induction of differentiation in teratocarcinoma stem cells by retinoic acid. Strickland, S., Mahdavi, V. Cell (1978) [Pubmed]
  12. Hormonal induction of differentiation in teratocarcinoma stem cells: generation of parietal endoderm by retinoic acid and dibutyryl cAMP. Strickland, S., Smith, K.K., Marotti, K.R. Cell (1980) [Pubmed]
  13. Independent mechanisms involved in suppression of the Moloney leukemia virus genome during differentiation of murine teratocarcinoma cells. Niwa, O., Yokota, Y., Ishida, H., Sugahara, T. Cell (1983) [Pubmed]
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  16. Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene. Joyner, A.L., Kornberg, T., Coleman, K.G., Cox, D.R., Martin, G.R. Cell (1985) [Pubmed]
  17. Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. Bischoff, F.R., Ponstingl, H. Nature (1991) [Pubmed]
  18. A functionally inactive p53 protein in teratocarcinoma cells is activated by either DNA damage or cellular differentiation. Lutzker, S.G., Levine, A.J. Nat. Med. (1996) [Pubmed]
  19. Repression of the IgH enhancer in teratocarcinoma cells associated with a novel octamer factor. Lenardo, M.J., Staudt, L., Robbins, P., Kuang, A., Mulligan, R.C., Baltimore, D. Science (1989) [Pubmed]
  20. Overexpression of the cellular retinoic acid binding protein-I (CRABP-I) results in a reduction in differentiation-specific gene expression in F9 teratocarcinoma cells. Boylan, J.F., Gudas, L.J. J. Cell Biol. (1991) [Pubmed]
  21. Trans-repressor activity of nuclear glycosaminoglycans on Fos and Jun/AP-1 oncoprotein-mediated transcription. Busch, S.J., Martin, G.A., Barnhart, R.L., Mano, M., Cardin, A.D., Jackson, R.L. J. Cell Biol. (1992) [Pubmed]
  22. Adhesive and degradative properties of human placental cytotrophoblast cells in vitro. Fisher, S.J., Cui, T.Y., Zhang, L., Hartman, L., Grahl, K., Zhang, G.Y., Tarpey, J., Damsky, C.H. J. Cell Biol. (1989) [Pubmed]
  23. UV irradiation induces the murine urokinase-type plasminogen activator gene via the c-Jun N-terminal kinase signaling pathway: requirement of an AP1 enhancer element. Miralles, F., Parra, M., Caelles, C., Nagamine, Y., Félez, J., Muñoz-Cánoves, P. Mol. Cell. Biol. (1998) [Pubmed]
  24. Regulation of insulin-like growth factor-dependent myoblast differentiation by Foxo forkhead transcription factors. Hribal, M.L., Nakae, J., Kitamura, T., Shutter, J.R., Accili, D. J. Cell Biol. (2003) [Pubmed]
  25. Cyclic AMP analogs and retinoic acid influence the expression of retinoic acid receptor alpha, beta, and gamma mRNAs in F9 teratocarcinoma cells. Hu, L., Gudas, L.J. Mol. Cell. Biol. (1990) [Pubmed]
  26. Endogenous assays of DNA methyltransferases: Evidence for differential activities of DNMT1, DNMT2, and DNMT3 in mammalian cells in vivo. Liu, K., Wang, Y.F., Cantemir, C., Muller, M.T. Mol. Cell. Biol. (2003) [Pubmed]
  27. Myocardin expression is regulated by Nkx2.5, and its function is required for cardiomyogenesis. Ueyama, T., Kasahara, H., Ishiwata, T., Nie, Q., Izumo, S. Mol. Cell. Biol. (2003) [Pubmed]
  28. Mouse cellular retinoic acid binding protein: cloning, complementary DNA sequence, and messenger RNA expression during the retinoic acid-induced differentiation of F9 wild type and RA-3-10 mutant teratocarcinoma cells. Stoner, C.M., Gudas, L.J. Cancer Res. (1989) [Pubmed]
  29. Isolation of cDNA clones specific for collagen IV and laminin from mouse teratocarcinoma cells. Wang, S.Y., Gudas, L.J. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  30. Molecular cloning of complementary DNA to mouse tissue plasminogen activator mRNA and its expression during F9 teratocarcinoma cell differentiation. Rickles, R.J., Darrow, A.L., Strickland, S. J. Biol. Chem. (1988) [Pubmed]
  31. Negative feedback control of the retinoid-retinoic acid/retinoid X receptor pathway by the human TR4 orphan receptor, a member of the steroid receptor superfamily. Lee, Y.F., Young, W.J., Burbach, J.P., Chang, C. J. Biol. Chem. (1998) [Pubmed]
  32. The beta 1,3-galactosyltransferase beta 3GalT-V is a stage-specific embryonic antigen-3 (SSEA-3) synthase. Zhou, D., Henion, T.R., Jungalwala, F.B., Berger, E.G., Hennet, T. J. Biol. Chem. (2000) [Pubmed]
  33. Antisperm antibodies in mouse vasectomy sera react with embryonal teratocarcinoma. Anderson, D.J., Adams, P.H., Hamilton, M.S., Alexander, N.J. J. Immunol. (1983) [Pubmed]
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