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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Teratocarcinoma

 
 
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Disease relevance of Teratocarcinoma

 

High impact information on Teratocarcinoma

  • It is likely that this represents the in vivo mechanism, as well, since extracts from L8 myoblasts specifically demethylate an alpha-actin gene, while extracts from F9 teratocarcinoma cells specifically demodify the Aprt CpG island [6].
  • The Ter mutation in laboratory mice is novel in that it acts codominantly to reduce germ cell numbers on many inbred strain backgrounds and to enhance dramatically inherited predisposition to spontaneous testicular teratocarcinomas in strain 129 inbred mice [7].
  • Cotransfection of c-jun and jun-B with or without c-fos into F9 teratocarcinoma cells results in decreased trans-activation of AP-1 compared with either gene alone [8].
  • Using F9 teratocarcinoma cells, which are unresponsive to cAMP, we initiated a series of transient expression experiments to establish a causal link between phosphorylation of CREB and trans-activation of cAMP-responsive genes [9].
  • Upon differentiation of mouse teratocarcinoma cell line F9 with retinoic acid and cAMP, the expression of both genes was drastically reduced, and in one instance was undetectable [10].
 

Chemical compound and disease context of Teratocarcinoma

 

Biological context of Teratocarcinoma

 

Anatomical context of Teratocarcinoma

 

Gene context of Teratocarcinoma

 

Analytical, diagnostic and therapeutic context of Teratocarcinoma

References

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  25. Cyclic AMP analogs and retinoic acid influence the expression of retinoic acid receptor alpha, beta, and gamma mRNAs in F9 teratocarcinoma cells. Hu, L., Gudas, L.J. Mol. Cell. Biol. (1990) [Pubmed]
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