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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ARHGEF4  -  Rho guanine nucleotide exchange factor...

Homo sapiens

Synonyms: APC-stimulated guanine nucleotide exchange factor 1, ASEF, ASEF1, Asef, Asef1, ...
 
 
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Disease relevance of ARHGEF4

  • A database search combined with screening of a human neuronal teratocarcinoma library identified two novel RhoGEFs, ARHGEF3 and ARHGEF4 (HGMW-approved symbols) [1].
  • Truncated mutant APCs present in colorectal tumour cells activate Asef constitutively and contribute to their aberrant migratory properties, which may be important for adenoma formation as well as tumour progression to invasive malignancy.Oncogene (2006) 25, 7538-7544. doi:10.1038/sj.onc.1210063 [2].
 

High impact information on ARHGEF4

  • Endogenous APC colocalized with Asef in mouse colon epithelial cells and neuronal cells [3].
  • In addition, APC interacts with the Rac-specific guanine nucleotide exchange factor Asef and stimulates its activity, thereby regulating the actin cytoskeletal network and cell morphology [4].
  • These results suggest that the APC-Asef complex functions in cell migration as well as in E-cadherin-mediated cell-cell adhesion, and that truncated APC present in colorectal tumour cells contributes to their aberrant migratory properties [4].
  • Experiments based on RNA interference and dominant-negative mutants show that both Asef and mutated APC are required for the migration of colorectal tumour cells expressing truncated APC [4].
  • APC interacts with Asef and stimulates its activity, thereby regulating the actin cytoskeletal network, cell morphology, adhesion and migration [2].
 

Biological context of ARHGEF4

  • ASEF showed high clonal diversity (32 PFGE types, 11 purK alleles, 4 AFLP genogroups), did not harbor putative virulence genes, and had no specific association with hospital acquisition [5].
 

Anatomical context of ARHGEF4

 

Enzymatic interactions of ARHGEF4

  • In contrast, various purified Asef protein fragments catalyzed the nucleotide exchange reaction of Cdc42 [7].
 

Other interactions of ARHGEF4

References

  1. Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22. Thiesen, S., Kübart, S., Ropers, H.H., Nothwang, H.G. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  2. Wnt signalling and the actin cytoskeleton. Akiyama, T., Kawasaki, Y. Oncogene (2006) [Pubmed]
  3. Asef, a link between the tumor suppressor APC and G-protein signaling. Kawasaki, Y., Senda, T., Ishidate, T., Koyama, R., Morishita, T., Iwayama, Y., Higuchi, O., Akiyama, T. Science (2000) [Pubmed]
  4. Mutated APC and Asef are involved in the migration of colorectal tumour cells. Kawasaki, Y., Sato, R., Akiyama, T. Nat. Cell Biol. (2003) [Pubmed]
  5. Population structure of Enterococcus faecium causing bacteremia in a Spanish university hospital: setting the scene for a future increase in vancomycin resistance? Coque, T.M., Willems, R.J., Fortún, J., Top, J., Diz, S., Loza, E., Cantón, R., Baquero, F. Antimicrob. Agents Chemother. (2005) [Pubmed]
  6. Adenomatous polyposis coli (Apc) tumor suppressor gene as a multifunctional gene. Senda, T., Shimomura, A., Iizuka-Kogo, A. Anatomical science international / Japanese Association of Anatomists. (2005) [Pubmed]
  7. Asef is a Cdc42-specific guanine nucleotide exchange factor. Gotthardt, K., Ahmadian, M.R. Biol. Chem. (2007) [Pubmed]
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