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Gene Review:

Nr1h2-ps - nuclear receptor subfamily 1, group H,...

Mus musculus

Synonyms: LXR-beta pseudogene, nuclear oxysterol receptor, psiLXR beta

Alberti, S. et al., Volle, D.H. et al., Alberti, S. et al., Peet, D.J. et al.

Alberti, Steffensen, Gustafsson,

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High impact information on Nr1h2-ps

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha [1].
The nuclear oxysterol-receptor paralogues LXRalpha and LXRbeta share a high degree of amino acid identity and bind endogenous oxysterol ligands with similar affinities [2].
Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes [3].
In addition, we show evidence for the presence of a processed, but truncated LXRbeta pseudogene in the mouse genome [4].

Other interactions of Nr1h2-ps

Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta [4].

References

Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Peet, D.J., Turley, S.D., Ma, W., Janowski, B.A., Lobaccaro, J.M., Hammer, R.E., Mangelsdorf, D.J. Cell (1998) [Pubmed]
Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice. Alberti, S., Schuster, G., Parini, P., Feltkamp, D., Diczfalusy, U., Rudling, M., Angelin, B., Björkhem, I., Pettersson, S., Gustafsson, J.A. J. Clin. Invest. (2001) [Pubmed]
Regulation of the aldo-keto reductase gene akr1b7 by the nuclear oxysterol receptor LXRalpha (liver X receptor-alpha) in the mouse intestine: putative role of LXRs in lipid detoxification processes. Volle, D.H., Repa, J.J., Mazur, A., Cummins, C.L., Val, P., Henry-Berger, J., Caira, F., Veyssiere, G., Mangelsdorf, D.J., Lobaccaro, J.M. Mol. Endocrinol. (2004) [Pubmed]
Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta. Alberti, S., Steffensen, K.R., Gustafsson, J.A. Gene (2000) [Pubmed]

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