Gene Review:
Nr1h3 - nuclear receptor subfamily 1, group H,...
Mus musculus
Synonyms:
AU018371, LXR, LXR alpha, Liver X receptor alpha, Lxra, ...
Kuipers,
Chimini,
Shan,
Havinga,
Siegler,
Thompson,
Groen,
Vanden Heuvel,
Plōsch,
Groot,
Halpern,
Dahlman-Wright,
Bloks,
Steffensen,
Lundholm,
Terasawa,
Savio,
Havinga,
Berdy,
Kok,
Gustafsson,
Schwartz,
Miller,
Bloks,
Chen,
Quinet,
Kruit,
Gillies,
Schwarz,
Movérare,
Nilsson,
Kema,
Kuipers,
Smit,
Kuipers,
Plösch,
Van Der Sluijs,
Boverhof,
Otsuki,
Frame,
Nambi,
Plösch,
Ohlsson,
Groen,
Groen,
- Inhibition of tumor growth and progression of LNCaP prostate cancer cells in athymic mice by androgen and liver X receptor agonist. Chuu, C.P., Hiipakka, R.A., Kokontis, J.M., Fukuchi, J., Chen, R.Y., Liao, S. Cancer Res. (2006)
- Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha. Tobin, K.A., Steineger, H.H., Alberti, S., Spydevold, O., Auwerx, J., Gustafsson, J.A., Nebb, H.I. Mol. Endocrinol. (2000)
- Hepatic peroxisomal fatty acid beta-oxidation is regulated by liver X receptor alpha. Hu, T., Foxworthy, P., Siesky, A., Ficorilli, J.V., Gao, H., Li, S., Christe, M., Ryan, T., Cao, G., Eacho, P., Michael, M.D., Michael, L.F. Endocrinology (2005)
- Identification of macrophage liver X receptors as inhibitors of atherosclerosis. Tangirala, R.K., Bischoff, E.D., Joseph, S.B., Wagner, B.L., Walczak, R., Laffitte, B.A., Daige, C.L., Thomas, D., Heyman, R.A., Mangelsdorf, D.J., Wang, X., Lusis, A.J., Tontonoz, P., Schulman, I.G. Proc. Natl. Acad. Sci. U.S.A. (2002)
- Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha. Dalen, K.T., Ulven, S.M., Bamberg, K., Gustafsson, J.A., Nebb, H.I. J. Biol. Chem. (2003)
- LXR-dependent gene expression is important for macrophage survival and the innate immune response. Joseph, S.B., Bradley, M.N., Castrillo, A., Bruhn, K.W., Mak, P.A., Pei, L., Hogenesch, J., O'connell, R.M., Cheng, G., Saez, E., Miller, J.F., Tontonoz, P. Cell (2004)
- Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha. Peet, D.J., Turley, S.D., Ma, W., Janowski, B.A., Lobaccaro, J.M., Hammer, R.E., Mangelsdorf, D.J. Cell (1998)
- Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta. Repa, J.J., Berge, K.E., Pomajzl, C., Richardson, J.A., Hobbs, H., Mangelsdorf, D.J. J. Biol. Chem. (2002)
- Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue. Laffitte, B.A., Chao, L.C., Li, J., Walczak, R., Hummasti, S., Joseph, S.B., Castrillo, A., Wilpitz, D.C., Mangelsdorf, D.J., Collins, J.L., Saez, E., Tontonoz, P. Proc. Natl. Acad. Sci. U.S.A. (2003)
- The Liver X Receptor (LXR) and Hepatic Lipogenesis: THE CARBOHYDRATE-RESPONSE ELEMENT-BINDING PROTEIN IS A TARGET GENE OF LXR. Cha, J.Y., Repa, J.J. J. Biol. Chem. (2007)
- Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production. Fowler, A.J., Sheu, M.Y., Schmuth, M., Kao, J., Fluhr, J.W., Rhein, L., Collins, J.L., Willson, T.M., Mangelsdorf, D.J., Elias, P.M., Feingold, K.R. J. Invest. Dermatol. (2003)
- The liver X-receptor alpha controls hepatic expression of the human bile acid-glucuronidating UGT1A3 enzyme in human cells and transgenic mice. Verreault, M., Senekeo-Effenberger, K., Trottier, J., Bonzo, J.A., Bélanger, J., Kaeding, J., Staels, B., Caron, P., Tukey, R.H., Barbier, O. Hepatology (2006)
- Distinct roles of insulin and liver X receptor in the induction and cleavage of sterol regulatory element-binding protein-1c. Hegarty, B.D., Bobard, A., Hainault, I., Ferré, P., Bossard, P., Foufelle, F. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Autoregulation of the human liver X receptor alpha promoter. Laffitte, B.A., Joseph, S.B., Walczak, R., Pei, L., Wilpitz, D.C., Collins, J.L., Tontonoz, P. Mol. Cell. Biol. (2001)
- Liver X receptor alpha interferes with SREBP1c-mediated Abcd2 expression. Novel cross-talk in gene regulation. Weinhofer, I., Kunze, M., Rampler, H., Bookout, A.L., Forss-Petter, S., Berger, J. J. Biol. Chem. (2005)
- Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model. Hashimoto, K., Cohen, R.N., Yamada, M., Markan, K.R., Monden, T., Satoh, T., Mori, M., Wondisford, F.E. J. Biol. Chem. (2006)
- The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions. Laffitte, B.A., Joseph, S.B., Chen, M., Castrillo, A., Repa, J., Wilpitz, D., Mangelsdorf, D., Tontonoz, P. Mol. Cell. Biol. (2003)
- Phospholipid transfer protein is regulated by liver X receptors in vivo. Cao, G., Beyer, T.P., Yang, X.P., Schmidt, R.J., Zhang, Y., Bensch, W.R., Kauffman, R.F., Gao, H., Ryan, T.P., Liang, Y., Eacho, P.I., Jiang, X.C. J. Biol. Chem. (2002)
- Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system. Whitney, K.D., Watson, M.A., Collins, J.L., Benson, W.G., Stone, T.M., Numerick, M.J., Tippin, T.K., Wilson, J.G., Winegar, D.A., Kliewer, S.A. Mol. Endocrinol. (2002)
- Increased hepatobiliary and fecal cholesterol excretion upon activation of the liver X receptor is independent of ABCA1. Plōsch, T., Kok, T., Bloks, V.W., Smit, M.J., Havinga, R., Chimini, G., Groen, A.K., Kuipers, F. J. Biol. Chem. (2002)
- Gene expression profiling identifies liver X receptor alpha as an estrogen-regulated gene in mouse adipose tissue. Lundholm, L., Movérare, S., Steffensen, K.R., Nilsson, M., Otsuki, M., Ohlsson, C., Gustafsson, J.A., Dahlman-Wright, K. J. Mol. Endocrinol. (2004)
- Sitosterolemia in ABC-transporter G5-deficient mice is aggravated on activation of the liver-X receptor. Plösch, T., Bloks, V.W., Terasawa, Y., Berdy, S., Siegler, K., Van Der Sluijs, F., Kema, I.P., Groen, A.K., Shan, B., Kuipers, F., Schwarz, M., Schwartz, M. Gastroenterology (2004)
- Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors. Joseph, S.B., Laffitte, B.A., Patel, P.H., Watson, M.A., Matsukuma, K.E., Walczak, R., Collins, J.L., Osborne, T.F., Tontonoz, P. J. Biol. Chem. (2002)
- Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR) in nutritional regulation of fatty acid metabolism. II. LXRs suppress lipid degradation gene promoters through inhibition of PPAR signaling. Ide, T., Shimano, H., Yoshikawa, T., Yahagi, N., Amemiya-Kudo, M., Matsuzaka, T., Nakakuki, M., Yatoh, S., Iizuka, Y., Tomita, S., Ohashi, K., Takahashi, A., Sone, H., Gotoda, T., Osuga, J., Ishibashi, S., Yamada, N. Mol. Endocrinol. (2003)
- Oxysterol-activated LXRalpha/RXR induces hSR-BI-promoter activity in hepatoma cells and preadipocytes. Malerød, L., Juvet, L.K., Hanssen-Bauer, A., Eskild, W., Berg, T. Biochem. Biophys. Res. Commun. (2002)
- Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor. Quinet, E.M., Savio, D.A., Halpern, A.R., Chen, L., Miller, C.P., Nambi, P. J. Lipid Res. (2004)
- Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. Castrillo, A., Joseph, S.B., Marathe, C., Mangelsdorf, D.J., Tontonoz, P. J. Biol. Chem. (2003)
- Increased fecal neutral sterol loss upon liver X receptor activation is independent of biliary sterol secretion in mice. Kruit, J.K., Plösch, T., Havinga, R., Boverhof, R., Groot, P.H., Groen, A.K., Kuipers, F. Gastroenterology (2005)
- Liver X receptor-alpha regulates proopiomelanocortin (POMC) gene transcription in the pituitary. Matsumoto, S., Hashimoto, K., Yamada, M., Satoh, T., Hirato, J., Mori, M. Mol. Endocrinol. (2009)
- Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver. Anderson, S.P., Dunn, C., Laughter, A., Yoon, L., Swanson, C., Stulnig, T.M., Steffensen, K.R., Chandraratna, R.A., Gustafsson, J.A., Corton, J.C. Mol. Pharmacol. (2004)
- LXR Alpha Transactivates Mouse Organic Solute Transporter Alpha and Beta via IR-1 Elements Shared with FXR. Okuwaki, M., Takada, T., Iwayanagi, Y., Koh, S., Kariya, Y., Fujii, H., Suzuki, H. Pharm. Res. (2007)
- Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X receptor-alpha. Vanden Heuvel, J.P., Thompson, J.T., Frame, S.R., Gillies, P.J. Toxicol. Sci. (2006)
- Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors. Mak, P.A., Kast-Woelbern, H.R., Anisfeld, A.M., Edwards, P.A. J. Lipid Res. (2002)