Gene Review:
Nr1h2 - nuclear receptor subfamily 1, group H,...
Mus musculus
Synonyms:
AI194859, LXR, LXRB, LXRbeta, Liver X receptor beta, ...
- Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha. Tobin, K.A., Steineger, H.H., Alberti, S., Spydevold, O., Auwerx, J., Gustafsson, J.A., Nebb, H.I. Mol. Endocrinol. (2000)
- Sterol regulatory element-binding protein 1 mediates liver X receptor-beta-induced increases in insulin secretion and insulin messenger ribonucleic acid levels. Zitzer, H., Wente, W., Brenner, M.B., Sewing, S., Buschard, K., Gromada, J., Efanov, A.M. Endocrinology (2006)
- LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function. Gerin, I., Dolinsky, V.W., Shackman, J.G., Kennedy, R.T., Chiang, S.H., Burant, C.F., Steffensen, K.R., Gustafsson, J.A., MacDougald, O.A. J. Biol. Chem. (2005)
- Unr is required in vivo for efficient initiation of translation from the internal ribosome entry sites of both rhinovirus and poliovirus. Boussadia, O., Niepmann, M., Créancier, L., Prats, A.C., Dautry, F., Jacquemin-Sablon, H. J. Virol. (2003)
- Placental expression of the nuclear receptors for oxysterols LXRalpha and LXRbeta during mouse and human development. Marceau, G., Volle, D.H., Gallot, D., Mangelsdorf, D.J., Sapin, V., Lobaccaro, J.M. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2005)
- Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta. Repa, J.J., Liang, G., Ou, J., Bashmakov, Y., Lobaccaro, J.M., Shimomura, I., Shan, B., Brown, M.S., Goldstein, J.L., Mangelsdorf, D.J. Genes Dev. (2000)
- Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient mice. Alberti, S., Schuster, G., Parini, P., Feltkamp, D., Diczfalusy, U., Rudling, M., Angelin, B., Björkhem, I., Pettersson, S., Gustafsson, J.A. J. Clin. Invest. (2001)
- Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice. Andersson, S., Gustafsson, N., Warner, M., Gustafsson, J.A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- Role of nucleotide- and base-excision repair in genotoxin-induced neuronal cell death. Kisby, G.E., Lesselroth, H., Olivas, A., Samson, L., Gold, B., Tanaka, K., Turker, M.S. DNA Repair (Amst.) (2004)
- Liver X Receptor (LXR)-beta Regulation in LXR{alpha}-Deficient Mice: Implications for Therapeutic Targeting. Quinet, E.M., Savio, D.A., Halpern, A.R., Chen, L., Schuster, G.U., Gustafsson, J.A., Basso, M.D., Nambi, P. Mol. Pharmacol. (2006)
- Induction of human liver X receptor alpha gene expression via an autoregulatory loop mechanism. Li, Y., Bolten, C., Bhat, B.G., Woodring-Dietz, J., Li, S., Prayaga, S.K., Xia, C., Lala, D.S. Mol. Endocrinol. (2002)
- Decreased nuclear hormone receptor expression in the livers of mice in late pregnancy. Sweeney, T.R., Moser, A.H., Shigenaga, J.K., Grunfeld, C., Feingold, K.R. Am. J. Physiol. Endocrinol. Metab. (2006)
- LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Laffitte, B.A., Repa, J.J., Joseph, S.B., Wilpitz, D.C., Kast, H.R., Mangelsdorf, D.J., Tontonoz, P. Proc. Natl. Acad. Sci. U.S.A. (2001)
- Structural characterisation of the mouse nuclear oxysterol receptor genes LXRalpha and LXRbeta. Alberti, S., Steffensen, K.R., Gustafsson, J.A. Gene (2000)
- Reduced fertility and inability of oocytes to resume meiosis in mice deficient of the Lxr genes. Steffensen, K.R., Robertson, K., Gustafsson, J.A., Andersen, C.Y. Mol. Cell. Endocrinol. (2006)
- Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype. Lund, E.G., Peterson, L.B., Adams, A.D., Lam, M.H., Burton, C.A., Chin, J., Guo, Q., Huang, S., Latham, M., Lopez, J.C., Menke, J.G., Milot, D.P., Mitnaul, L.J., Rex-Rabe, S.E., Rosa, R.L., Tian, J.Y., Wright, S.D., Sparrow, C.P. Biochem. Pharmacol. (2006)
- Sterol intermediates from cholesterol biosynthetic pathway as liver x receptor ligands. Yang, C., McDonald, J.G., Patel, A., Zhang, Y., Umetani, M., Xu, F., Westover, E.J., Covey, D.F., Mangelsdorf, D.J., Cohen, J.C., Hobbs, H.H. J. Biol. Chem. (2006)
- Liver X receptor agonist TO-901317 upregulates SCD1 expression in renal proximal straight tubule. Zhang, Y., Zhang, X., Chen, L., Wu, J., Su, D., Lu, W.J., Hwang, M.T., Yang, G., Li, S., Wei, M., Davis, L., Breyer, M.D., Guan, Y. Am. J. Physiol. Renal Physiol. (2006)
- Oxysterol-activated LXRalpha/RXR induces hSR-BI-promoter activity in hepatoma cells and preadipocytes. Malerød, L., Juvet, L.K., Hanssen-Bauer, A., Eskild, W., Berg, T. Biochem. Biophys. Res. Commun. (2002)
- Liver X receptor-dependent repression of matrix metalloproteinase-9 expression in macrophages. Castrillo, A., Joseph, S.B., Marathe, C., Mangelsdorf, D.J., Tontonoz, P. J. Biol. Chem. (2003)
- Liver X receptor agonists inhibit tissue factor expression in macrophages. Terasaka, N., Hiroshima, A., Ariga, A., Honzumi, S., Koieyama, T., Inaba, T., Fujiwara, T. FEBS J. (2005)
- Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor alpha, retinoid X receptor, and liver X receptor in mouse liver. Anderson, S.P., Dunn, C., Laughter, A., Yoon, L., Swanson, C., Stulnig, T.M., Steffensen, K.R., Chandraratna, R.A., Gustafsson, J.A., Corton, J.C. Mol. Pharmacol. (2004)
- Liver X receptor gene polymorphisms and adipose tissue expression levels in obesity. Dahlman, I., Nilsson, M., Jiao, H., Hoffstedt, J., Lindgren, C.M., Humphreys, K., Kere, J., Gustafsson, J.A., Arner, P., Dahlman-Wright, K. Pharmacogenet. Genomics (2006)