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Gene Review

Uba2  -  ubiquitin-like modifier activating enzyme 2

Mus musculus

Synonyms: AA986091, Anthracycline-associated resistance ARX, Arx, SAE2, SUMO-activating enzyme subunit 2, ...
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High impact information on Sae2

  • Differences in peptide structure, however, like those exemplified by SAEP-2 and SAEP-4, may differentially affect the endotoxin-neutralizing potency of these peptides despite similar binding activity against lipid A, reflecting possible differences in peptide solubility or peptide regulation of intracellular signal transduction [1].
  • Our in silico search for candidate genes noted that annotation of a human Xp22 PAC (RPCI1-258N20) sequence (GenBank Accession No. AC002504) identified putative exons consistent with an Arx homologue in Xp22 [2].


  1. Influence of synthetic antiendotoxin peptides on lipopolysaccharide (LPS) recognition and LPS-induced proinflammatory cytokine responses by cells expressing membrane-bound CD14. Iwagaki, A., Porro, M., Pollack, M. Infect. Immun. (2000) [Pubmed]
  2. Human ARX gene: genomic characterization and expression. Ohira, R., Zhang, Y.H., Guo, W., Dipple, K., Shih, S.L., Doerr, J., Huang, B.L., Fu, L.J., Abu-Khalil, A., Geschwind, D., McCabe, E.R. Mol. Genet. Metab. (2002) [Pubmed]
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