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Gene Review

UBA2  -  ubiquitin-like modifier activating enzyme 2

Homo sapiens

Synonyms: ARX, Anthracycline-associated resistance ARX, FLJ13058, HRIHFB2115, SAE2, ...
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High impact information on SAE2

  • Although the interaction of UBA2 with Lys48-linked diubiquitin involves the same hydrophobic surface on each ubiquitin unit as that utilized in monoubiquitin:UBA complexes, our results show how the "closed" conformation of Lys48-linked diubiquitin is crucial for high-affinity binding [1].
  • Here, we use NMR to unveil the structural basis of selective recognition of Lys48-linked di- and tetraubiquitin chains by the UBA2 domain of hHR23A [1].
  • We report here that the adenoviral protein Gam1 inhibits the SUMO pathway by interfering with the activity of E1 (SAE1/SAE2) [2].
  • The human UBA2 gene is located on chromosome 19q12 [3].

Other interactions of SAE2

  • Human AOS1 is homologous to the N-terminal half of E1, whereas human UBA2 is homologous to the C-terminal half of E1 [3].

Analytical, diagnostic and therapeutic context of SAE2


  1. Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain. Varadan, R., Assfalg, M., Raasi, S., Pickart, C., Fushman, D. Mol. Cell (2005) [Pubmed]
  2. A mechanism for inhibiting the SUMO pathway. Boggio, R., Colombo, R., Hay, R.T., Draetta, G.F., Chiocca, S. Mol. Cell (2004) [Pubmed]
  3. Molecular cloning and characterization of human AOS1 and UBA2, components of the sentrin-activating enzyme complex. Gong, L., Li, B., Millas, S., Yeh, E.T. FEBS Lett. (1999) [Pubmed]
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