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Gene Review

TXNDC11  -  thioredoxin domain containing 11

Homo sapiens

Synonyms: EF-hand-binding protein 1, EFP1, Thioredoxin domain-containing protein 11
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High impact information on TXNDC11

  • EFP1 and Duox mRNA share similar distribution in nine different tissues [1].
  • EFP1 can be co-immunoprecipitated with Duoxs in transfected COS cells as well as in primary cultured human thyrocytes [1].
  • These results suggest that EFP1 could be one of the partners in the assembly of the multiprotein complex constituting the thyroid H(2)O(2) generating system but is certainly not sufficient to permit H(2)O(2) generation [1].


  1. Identification of a novel partner of duox: EFP1, a thioredoxin-related protein. Wang, D., De Deken, X., Milenkovic, M., Song, Y., Pirson, I., Dumont, J.E., Miot, F. J. Biol. Chem. (2005) [Pubmed]
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