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Gene Review

DBR1  -  debranching RNA lariats 1

Homo sapiens

Synonyms: Lariat debranching enzyme
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Disease relevance of DBR1


High impact information on DBR1

  • In this work we report on a Dbr1p-dependent RNA decay pathway that limits the accumulation of splice-defective lariat intermediates stalled at the second step of splicing [2].
  • In this pathway, splice-defective lariat intermediates are debranched by Dbr1p and subsequently degraded 5' to 3' primarily by the cytoplasmic exonuclease, Xrn1p [2].
  • Frequency of TD was analyzed according to patients' sex, therapy scheme, HCV genotype and HLA DBR1 alleles [3].
  • Integration of the cDNA for hDBR1 into the ura4 locus of S. pombe also complemented both the intron accumulation and slow growth phenotypes of a S. pombe dbr1 null mutant strain [1].
  • Comparison of the amino acid sequence of hDBR1 with the other DBR protein sequences showed several conserved regions, with 40, 44 and 43% identity to the S. cerevisiae, S. pombe and C. elegans debranching enzymes, respectively [1].


  1. Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants. Kim, J.W., Kim, H.C., Kim, G.M., Yang, J.M., Boeke, J.D., Nam, K. Nucleic Acids Res. (2000) [Pubmed]
  2. Cytoplasmic degradation of splice-defective pre-mRNAs and intermediates. Hilleren, P.J., Parker, R. Mol. Cell (2003) [Pubmed]
  3. Thyroid gland dysfunctions during antiviral therapy of chronic hepatitis C. Kryczka, W., Brojer, E., Kowalska, A., Zarebska-Michaluk, D. Med. Sci. Monit. (2001) [Pubmed]
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