The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • OMIM
  • SNPedia
  • UniProt
  • Ensembl
  • HGNC

Table of contents

About

Terms

 

Gene Review: 

CRBN  -  cereblon

Homo sapiens

Synonyms: AD-006, MRT2, MRT2A, Protein cereblon
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Psychiatry related information on CRBN

 

High impact information on CRBN

  • Candidate genes for recessive non-syndromic mental retardation on chromosome 3p (MRT2A) [2].
  • Only two autosomal genes, the PRSS12 gene on chromosome 4q26 and the CRBN on chromosome 3p26, have been shown to cause autosomal recessive NSMR, each gene in only one family [3].
  • We suggest that 3p- syndrome associated features are primarily caused by loss of CNTN4 and CRBN, with loss of CHL1 probably having an additional detrimental effect on the cognitive functioning of the present patient [1].
  • The mutation in the CRBN gene described interrupts an N-myristoylation site and eliminates a casein kinase II phosphorylation site at the C terminus [4].

References

  1. FISH and array-CGH analysis of a complex chromosome 3 aberration suggests that loss of CNTN4 and CRBN contributes to mental retardation in 3pter deletions. Dijkhuizen, T., van Essen, T., van der Vlies, P., Verheij, J.B., Sikkema-Raddatz, B., van der Veen, A.Y., Gerssen-Schoorl, K.B., Buys, C.H., Kok, K. Am. J. Med. Genet. A (2006) [Pubmed]
  2. Candidate genes for recessive non-syndromic mental retardation on chromosome 3p (MRT2A). Higgins, J.J., Pucilowska, J., Lombardi, R.Q., Rooney, J.P. Clin. Genet. (2004) [Pubmed]
  3. The CC2D1A, a member of a new gene family with C2 domains, is involved in autosomal recessive non-syndromic mental retardation. Basel-Vanagaite, L., Attia, R., Yahav, M., Ferland, R.J., Anteki, L., Walsh, C.A., Olender, T., Straussberg, R., Magal, N., Taub, E., Drasinover, V., Alkelai, A., Bercovich, D., Rechavi, G., Simon, A.J., Shohat, M. J. Med. Genet. (2006) [Pubmed]
  4. A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation. Higgins, J.J., Pucilowska, J., Lombardi, R.Q., Rooney, J.P. Neurology (2004) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities