Disease relevance of PRSS12

• A new human cell line MRT-1 was established from a metastatic lymph node of renal cell carcinoma of a 47 years old Japanese male [1].

High impact information on PRSS12

• Leydin is clearly distinct from acrosin, the other testis-specific serine protease which is expressed by the spermatocytes [2].
• Cloning and structural analysis of leydin, a novel human serine protease expressed by the Leydig cells of the testis [2].
• The rate of positivity in all patients was 63.6% for tyrosinase, 50% for MRT-1 and 77.3% for at least one molecular marker [3].
• Only two autosomal genes, the PRSS12 gene on chromosome 4q26 and the CRBN on chromosome 3p26, have been shown to cause autosomal recessive NSMR, each gene in only one family [4].
• Establishment and characterization of a human renal carcinoma cell line MRT-1, with special reference to the production of serine proteinase inhibitors [1].

Anatomical context of PRSS12

• The cultured MRT-1 cells exhibit an epithelial appearance and contain lipid vacuoles in their cytoplasm in vitro [1].

Other interactions of PRSS12

• Most of the MRT-1 derived alpha 1-AT had lost the affinity to Concanavalin A when compared to the normal plasma alpha 1-AT [1].

Analytical, diagnostic and therapeutic context of PRSS12

• The MRT1 based perfusion model [5].

References