Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

NGRN - neugrin, neurite outgrowth associated

Homo sapiens

Synonyms: DSC92, FI58G, HT020, Mesenchymal stem cell protein DSC92, Neugrin, ...

Ishigaki, S. et al.

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Disease relevance of NGRN

Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells [1].

High impact information on NGRN

Neugrin and m-Neugrin are 70% homologous in amino acid sequence [1].
Northern analysis revealed that neugrin was strongly expressed in the heart, brain, and skeletal muscle, and m-neugrin in the liver, kidney, and brain [1].
We herein report two new genes, human neugrin and mouse homologue m-neugrin, found by screening the cDNA library for the human spinal cord [1].
Although the expression of neugrin was found to be ubiquitous in the nervous system, in situ hybridization showed that both neugrin and m-neugrin were expressed mainly in the neurons rather than the glial cells [1].

Biological context of NGRN

The neugrin mRNA encodes 219 amino acids and its deduced amino acid sequence contains an NLS-like domain [1].

References

Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells. Ishigaki, S., Niwa, J., Yoshihara, T., Mitsuma, N., Doyu, M., Sobue, G. Biochem. Biophys. Res. Commun. (2000) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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