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Gene Review

SFMBT1  -  Scm-like with four mbt domains 1

Homo sapiens

Synonyms: DKFZp434L243, RU1, Renal ubiquitous protein 1, SFMBT, Scm-like with four MBT domains protein 1, ...
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Disease relevance of SFMBT1

  • Investigations were done to determine whether vaccines prepared with chemically killed Staphylococcus haemolyticus RU1 and Streptococcus bovis AV46 (bacteria that have been demonstrated to express human choriogonadotropin [hCG]-like material on their surface) elicited antibodies in rabbits with specificity for hCG determinants [1].

High impact information on SFMBT1

  • Purified or plasma vWF was immobilized with a monoclonal antibody (MoAb RU1) covalently linked to Sepharose (Pharmacia LKB Biotechnology, Uppsala, Sweden) [2].
  • Restriction mapping and sequence analysis show that each S232 unit contains 5 kb of unique sequence in addition to two elements, RU1 and RU2, composed of a variable number of tandem repeats [3].
  • 3. RU1 and RU2 were also generated from [(14)C]M17055 after incubation with human liver microsomes, suggesting that the metabolic pathway of M17055 in humans involves that observed in rats [4].

Analytical, diagnostic and therapeutic context of SFMBT1

  • The RU-1, RX-1 and AG-73 peptides were tested for their ability to support cell attachment and to bind the cell surface of DU-H prostate carcinoma cells in suspension using fluorescence-activated cell-sorting (FACS) analysis [5].


  1. Antibodies to bacterial vaccines demonstrating specificity for human choriogonadotropin (hCG) and immunochemical detection of hCG-like factor in subcellular bacterial fractions. Domingue, G.J., Acevedo, H.F., Powell, J.E., Stevens, V.C. Infect. Immun. (1986) [Pubmed]
  2. Kinetics of factor VIII-von Willebrand factor association. Vlot, A.J., Koppelman, S.J., Meijers, J.C., Dama, C., van den Berg, H.M., Bouma, B.N., Sixma, J.J., Willems, G.M. Blood (1996) [Pubmed]
  3. Characterization of a low copy repetitive element S232 involved in the generation of frequent deletions of the distal short arm of the human X chromosome. Li, X.M., Yen, P.H., Shapiro, L.J. Nucleic Acids Res. (1992) [Pubmed]
  4. Studies on the metabolic fate of M17055, a novel diuretic (4): species difference in metabolic pathway and identification of human CYP isoform responsible for the metabolism of M17055. Nakajima, H., Nakanishi, T., Nakai, K., Matsumoto, S., Ida, K., Ogihara, T., Ohzawa, N. Drug Metab. Pharmacokinet. (2002) [Pubmed]
  5. The use of a combinatorial library method to isolate human tumor cell adhesion peptides. Pennington, M.E., Lam, K.S., Cress, A.E. Mol. Divers. (1996) [Pubmed]
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