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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Biotechnology

  • Our analysis demonstrates that IFN alfa-2b offers substantial clinical and cost advantages to patients with hairy cell leukemia and that the introduction of this therapy using novel biotechnology furthers the health care community's commitment to cost containment [1].
  • Using the National Center for Biotechnology Information Serial Analysis of Gene Expression database, we found that S100A4, a calcium-binding protein previously implicated in metastasis, was expressed in five of seven pancreatic carcinoma libraries but not in the two normal pancreatic duct libraries [2].
  • This trend has not been lost on the emerging biotechnology industry, which tends to view MS as both a disease to be explored on its own and as a disease whose solution may also open doors into other chronic diseases of purported autoimmune etiology, such as rheumatoid arthritis, type I diabetes, and others [3].
  • This has allowed the development of a balanced-lethal system for the expression of heterologous antigens in vaccine strains using vectors containing the wild-type asd gene from Streptococcus mutans and asd mutant Salmonella hosts [Nakayama et al., Biotechnology 6 (1988) 693-697] [4].
  • Mauran, an exopolysaccharide produced by the halophilic bacterium Halomonas maura, with a novel composition and interesting properties for biotechnology [5].

High impact information on Biotechnology


Chemical compound and disease context of Biotechnology


Biological context of Biotechnology


Anatomical context of Biotechnology

  • The new tar alleles and the techniques described here provide a new approach for exploring the relationship between ligand binding and signal transduction by chemoreceptors and for engineering new receptors for applications in biotechnology [18].
  • Moreover, clinical trials investigating the putative neuroprotective and neuroregenerative properties ascribed to the Rho pathway antagonist, Cethrin((R)) (BioAxone Therapeutic, Inc.), and implantation of activated autologous macrophages (ProCord((R)); Proneuron Biotechnologies) in patients with thoracic and cervical SCI are now underway [19].
  • We evaluated two commercial human T-cell lymphotropic virus (HTLV) Western blot (WB; immunoblot) kits, Cambridge Biotech Corp. (CBC) and Diagnostic Biotechnology Ltd. (DBL) [20].
  • A new biotechnology for articular cartilage repair: subchondral implantation of a composite of interconnected porous hydroxyapatite, synthetic polymer (PLA-PEG), and bone morphogenetic protein-2 (rhBMP-2) [21].
  • Normal and injured rat molars (dentin cavity for 4 h, 16-24 h, 3 days, 16 days, or 5 weeks) were immunoreacted using the ABC detection system for two anti-trkA antibodies (sTA, Santa Cruz Biotechnology; rTA, L. Reichardt) and antibodies against p75 and NGF, all of which also stained pulpal nerve fibers [22].

Associations of Biotechnology with chemical compounds

  • This is of significant interest within the field of biotechnology since galactose is present in many industrial media [23].
  • The accumulation of the 33-kDa cysteine protease in response to caterpillar feeding, and its ability to damage the insect peritrophic matrix, represents an unusual host-plant resistance mechanism that may have applications in agricultural biotechnology [24].
  • Examples of present and future applications of biotechnology to lactic acid bacteria to improve product quality are described [25].
  • Oxidative damage to the sulfur-containing amino acids, methionine and cysteine, is a major concern in biotechnology and medicine. alpha1-Antitrypsin, which is a metastable and conformationally flexible protein that belongs to the serpin family of protease inhibitors, contains nine methionines and a single cysteine in its primary sequence [26].
  • Advances in liposome design are leading to new applications for the delivery of new biotechnology products, such as recombinant proteins, antisense oligonucleotides and cloned genes [27].

Gene context of Biotechnology


Analytical, diagnostic and therapeutic context of Biotechnology


  1. Cost-benefit analysis of interferon alfa-2b in treatment of hairy cell leukemia. Ozer, H., Golomb, H.M., Zimmerman, H., Spiegel, R.J. J. Natl. Cancer Inst. (1989) [Pubmed]
  2. Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. Rosty, C., Ueki, T., Argani, P., Jansen, M., Yeo, C.J., Cameron, J.L., Hruban, R.H., Goggins, M. Am. J. Pathol. (2002) [Pubmed]
  3. Advances in the understanding and treatment of multiple sclerosis. Boston, Massachusetts, USA, 28-29 October 1992. Reingold, S.C. J. Neuroimmunol. (1993) [Pubmed]
  4. Cloning and characterization of the asd gene of Salmonella typhimurium: use in stable maintenance of recombinant plasmids in Salmonella vaccine strains. Galán, J.E., Nakayama, K., Curtiss, R. Gene (1990) [Pubmed]
  5. Mauran, an exopolysaccharide produced by the halophilic bacterium Halomonas maura, with a novel composition and interesting properties for biotechnology. Arias, S., del Moral, A., Ferrer, M.R., Tallon, R., Quesada, E., Béjar, V. Extremophiles (2003) [Pubmed]
  6. Gel microdrop technology for rapid isolation of rare and high producer cells. Weaver, J.C., McGrath, P., Adams, S. Nat. Med. (1997) [Pubmed]
  7. EC biotechnology policy. Progress on animal patents. Aldhous, P. Nature (1992) [Pubmed]
  8. Biotechnology. Yellow light on L-tryptophan. Aldhous, P. Nature (1991) [Pubmed]
  9. Biotechnology: Wellcome drops TPA. Gershon, D. Nature (1990) [Pubmed]
  10. UK biotechnology. Biotechnology no longer Wellcome. Aldhous, P. Nature (1990) [Pubmed]
  11. High pressure-sensitive gene expression in Lactobacillus sanfranciscensis. Vogel, R.F., Pavlovic, M., Hörmann, S., Ehrmann, M.A. Braz. J. Med. Biol. Res. (2005) [Pubmed]
  12. Abiraterone. Cougar Biotechnology. Madan, R.A., Arlen, P.M. IDrugs : the investigational drugs journal. (2006) [Pubmed]
  13. Rheumatoid arthritis. Lee, D.M., Weinblatt, M.E. Lancet (2001) [Pubmed]
  14. Molecular biology of methanogens. Reeve, J.N. Annu. Rev. Microbiol. (1992) [Pubmed]
  15. Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9). Phay, J.E., Hussain, H.B., Moley, J.F. Genomics (2000) [Pubmed]
  16. Autologous osteoblasts enhance osseointegration of porous titanium implants. Frosch, K.H., Sondergeld, I., Dresing, K., Rudy, T., Lohmann, C.H., Rabba, J., Schild, D., Breme, J., Stuermer, K.M. J. Orthop. Res. (2003) [Pubmed]
  17. Production, purification, and properties of an extracellular laccase from Rigidoporus lignosus. Cambria, M., Cambria, A., Ragusa, S., Rizzarelli, E. Protein Expr. Purif. (2000) [Pubmed]
  18. Changing the specificity of a bacterial chemoreceptor. Derr, P., Boder, E., Goulian, M. J. Mol. Biol. (2006) [Pubmed]
  19. Pharmacological approaches to repair the injured spinal cord. Baptiste, D.C., Fehlings, M.G. J. Neurotrauma (2006) [Pubmed]
  20. Evaluation of two commercial human T-cell lymphotropic virus western blot (immunoblot) kits with problem specimens. Gallo, D., Diggs, J.L., Hanson, C.V. J. Clin. Microbiol. (1994) [Pubmed]
  21. A new biotechnology for articular cartilage repair: subchondral implantation of a composite of interconnected porous hydroxyapatite, synthetic polymer (PLA-PEG), and bone morphogenetic protein-2 (rhBMP-2). Tamai, N., Myoui, A., Hirao, M., Kaito, T., Ochi, T., Tanaka, J., Takaoka, K., Yoshikawa, H. Osteoarthr. Cartil. (2005) [Pubmed]
  22. Neurotrophin receptors and nerve growth factor are differentially expressed in adjacent nonneuronal cells of normal and injured tooth pulp. Woodnutt, D.A., Wager-Miller, J., O'Neill, P.C., Bothwell, M., Byers, M.R. Cell Tissue Res. (2000) [Pubmed]
  23. Increasing galactose consumption by Saccharomyces cerevisiae through metabolic engineering of the GAL gene regulatory network. Ostergaard, S., Olsson, L., Johnston, M., Nielsen, J. Nat. Biotechnol. (2000) [Pubmed]
  24. Insect feeding mobilizes a unique plant defense protease that disrupts the peritrophic matrix of caterpillars. Pechan, T., Cohen, A., Williams, W.P., Luthe, D.S. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  25. Applications for biotechnology: present and future improvements in lactic acid bacteria. McKay, L.L., Baldwin, K.A. FEMS Microbiol. Rev. (1990) [Pubmed]
  26. The reactivity and oxidation pathway of cysteine 232 in recombinant human alpha 1-antitrypsin. Griffiths, S.W., King, J., Cooney, C.L. J. Biol. Chem. (2002) [Pubmed]
  27. Recent advances in liposomal drug-delivery systems. Chonn, A., Cullis, P.R. Curr. Opin. Biotechnol. (1995) [Pubmed]
  28. Immunohistochemical detection of HER-2/neu, c-kit (CD117) and vascular endothelial growth factor (VEGF) overexpression in soft tissue sarcomas. Potti, A., Ganti, A.K., Foster, H., Knox, S., Hebert, B.J., Tendulkar, K., Sholes, K., Koch, M., Kargas, S. Anticancer Res. (2004) [Pubmed]
  29. Identification of 45 novel SNPs in the 83-kb region containing peptidylarginine deiminase types 1 and 3 loci on chromosomal band 1p36.13. Iida, A., Nakamura, Y. J. Hum. Genet. (2004) [Pubmed]
  30. Biologic agents in the treatment of rheumatoid arthritis. Haraoui, B., Strand, V., Keystone, E. Current pharmaceutical biotechnology. (2000) [Pubmed]
  31. Application of the PHO5-gene-fusion technology to molecular genetics and biotechnology in yeast. Harashima, S., Kaneko, Y. J. Biosci. Bioeng. (2001) [Pubmed]
  32. Overview of bone morphogenetic proteins. Wozney, J.M. Spine. (2002) [Pubmed]
  33. Applied biosensors. Freitag, R. Curr. Opin. Biotechnol. (1993) [Pubmed]
  34. Stacked-unstacked equilibrium at the nick site of DNA. Protozanova, E., Yakovchuk, P., Frank-Kamenetskii, M.D. J. Mol. Biol. (2004) [Pubmed]
  35. Expression of nuclear factor-kappa B and I kappa B alpha proteins in prostatic adenocarcinomas: correlation of nuclear factor-kappa B immunoreactivity with disease recurrence. Ross, J.S., Kallakury, B.V., Sheehan, C.E., Fisher, H.A., Kaufman, R.P., Kaur, P., Gray, K., Stringer, B. Clin. Cancer Res. (2004) [Pubmed]
  36. Capillary electrophoresis sodium dodecyl sulfate nongel sieving analysis of a therapeutic recombinant monoclonal antibody: a biotechnology perspective. Hunt, G., Nashabeh, W. Anal. Chem. (1999) [Pubmed]
  37. Genetic variants of alpha 1-antitrypsin and hemoglobin typed by isoelectric focusing in preselected narrow pH gradients with PhastSystem. Jeppsson, J.O., Einarsson, R. Clin. Chem. (1992) [Pubmed]
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