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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

UBE2J1  -  ubiquitin-conjugating enzyme E2, J1

Homo sapiens

Synonyms: CGI-76, HSPC153, HSPC205, HSU93243, HsUBC6e, ...
 
 
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High impact information on UBE2J1

  • The occurrence of two distinct Ubc6p homologs in vertebrates, including one with phosphorylation modification in response to ER stress, emphasizes diversity in function between these Ub-conjugating enzymes during ERAD processes [1].
  • Human homologs of Ubc6p ubiquitin-conjugating enzyme and phosphorylation of HsUbc6e in response to endoplasmic reticulum stress [1].
  • In conclusion, Ubc6p and Ubc7p are required for normal and substrate-induced ubiquitination and proteolysis of D2 [2].
  • Ubc6p and ubc7p are required for normal and substrate-induced endoplasmic reticulum-associated degradation of the human selenoprotein type 2 iodothyronine monodeiodinase [2].
  • Chick NCUBE1 transcripts were detected in all tissues examined and decreased threefold during chondrocyte terminal differentiation [3].

References

  1. Human homologs of Ubc6p ubiquitin-conjugating enzyme and phosphorylation of HsUbc6e in response to endoplasmic reticulum stress. Oh, R.S., Bai, X., Rommens, J.M. J. Biol. Chem. (2006) [Pubmed]
  2. Ubc6p and ubc7p are required for normal and substrate-induced endoplasmic reticulum-associated degradation of the human selenoprotein type 2 iodothyronine monodeiodinase. Botero, D., Gereben, B., Goncalves, C., De Jesus, L.A., Harney, J.W., Bianco, A.C. Mol. Endocrinol. (2002) [Pubmed]
  3. Identification of a family of noncanonical ubiquitin-conjugating enzymes structurally related to yeast UBC6. Lester, D., Farquharson, C., Russell, G., Houston, B. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
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