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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

UBE2G1  -  ubiquitin-conjugating enzyme E2G 1

Homo sapiens

Synonyms: E217K, UBC7, UBE2G, Ubiquitin carrier protein G1, Ubiquitin-conjugating enzyme E2 G1, ...
 
 
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High impact information on UBE2G1

  • The antithrombotic properties of E217K thrombin are derived from its inability to convert fibrinogen to a fibrin clot while maintaining its thrombomodulin-dependent ability to activate the anticoagulant protein C pathway [1].
  • Here we describe the 2.5-A crystal structure of human E217K thrombin, which displays a dramatic restructuring of the geometry of the active site [1].
  • This quest culminated in the identification of the E217K variant through scanning and saturation mutagenesis [1].
  • Mammalian UBC6 (MmUBC6) does not directly associate with D2 but can associate with a complex containing UBC7 and D2 [2].
  • Ubc6p and ubc7p are required for normal and substrate-induced endoplasmic reticulum-associated degradation of the human selenoprotein type 2 iodothyronine monodeiodinase [3].
 

Biological context of UBE2G1

  • The cDNA, designated UBE2G, contained an open reading frame of 510 nucleotides encoding 170 amino acids [4].
  • D2 inactivation is mediated by selective UBC-7-mediated conjugation to ubiquitin, a process that is accelerated by T4 catalysis, thus maintaining local T3 homeostasis [5].
  • Levels of specific ubiquitin conjugating enzymes, Ubc7 and Ubc10, increased 6 and 2-fold at the G2/M phase and S/G2/M phases, respectively [6].
  • The up-regulation of Ubc7 and Ubc10 during the G2/M and S/G2/M phases suggests that these enzymes may be involved in controlling the cell cycle progression at this phase [6].
 

Associations of UBE2G1 with chemical compounds

  • In conclusion, D2 ERAD in human cells proceeds via an association between UBC7 and the carboxyl region of D2, a unique mechanism for the control of thyroid hormone activation [2].
 

Other interactions of UBE2G1

  • These findings revealed that CYP3A4DeltaCT was also degraded by Ubc7p-26S proteasomal pathway, thereby indicating that this CT heptapeptide is not critical for CYP3A4 proteasomal degradation [7].
 

Analytical, diagnostic and therapeutic context of UBE2G1

  • We show that the isolated TEB4 RING domain catalyses ubiquitin ligation in vitro in a reaction that is ubiquitin Lys48-specific and involves UBC7 (ubiquitin-conjugating enzyme 7) [8].

References

  1. Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery. Carter, W.J., Myles, T., Gibbs, C.S., Leung, L.L., Huntington, J.A. J. Biol. Chem. (2004) [Pubmed]
  2. Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2. Kim, B.W., Zavacki, A.M., Curcio-Morelli, C., Dentice, M., Harney, J.W., Larsen, P.R., Bianco, A.C. Mol. Endocrinol. (2003) [Pubmed]
  3. Ubc6p and ubc7p are required for normal and substrate-induced endoplasmic reticulum-associated degradation of the human selenoprotein type 2 iodothyronine monodeiodinase. Botero, D., Gereben, B., Goncalves, C., De Jesus, L.A., Harney, J.W., Bianco, A.C. Mol. Endocrinol. (2002) [Pubmed]
  4. Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans. Watanabe, T.K., Kawai, A., Fujiwara, T., Maekawa, H., Hirai, Y., Nakamura, Y., Takahashi, E. Cytogenet. Cell Genet. (1996) [Pubmed]
  5. Triplets! Unexpected structural similarity among the three enzymes that catalyze initiation and termination of thyroid hormone effects. Bianco, A.C. Arquivos brasileiros de endocrinologia e metabologia. (2004) [Pubmed]
  6. Regulation of the ubiquitin proteasome pathway in human lens epithelial cells during the cell cycle. Liu, Q., Shang, F., Guo, W., Hobbs, M., Valverde, P., Reddy, V., Taylor, A. Exp. Eye Res. (2004) [Pubmed]
  7. Endoplasmic reticulum-associated degradation of cytochrome P450 CYP3A4 in Saccharomyces cerevisiae: further characterization of cellular participants and structural determinants. Liao, M., Faouzi, S., Karyakin, A., Correia, M.A. Mol. Pharmacol. (2006) [Pubmed]
  8. TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum. Hassink, G., Kikkert, M., van Voorden, S., Lee, S.J., Spaapen, R., van Laar, T., Coleman, C.S., Bartee, E., Früh, K., Chau, V., Wiertz, E. Biochem. J. (2005) [Pubmed]
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