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Gene Review

ZC3HC1  -  zinc finger, C3HC-type containing 1

Homo sapiens

Synonyms: HSPC216, NIPA, Nuclear-interacting partner of ALK, Nuclear-interacting partner of anaplastic lymphoma kinase, Zinc finger C3HC-type protein 1, ...
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High impact information on ZC3HC1

  • In NPM-ALK-transformed Ba/F3 cells, apoptosis triggered by wortmannin treatment was enhanced by overexpression of putative dominant-negative NIPA mutants [1].
  • Overexpression of NIPA in Ba/F3 cells was able to protect from apoptosis induced by IL-3 withdrawal [1].
  • Mutations of the nuclear translocation signal or the Ser-354 phosphorylation site impaired the antiapoptotic function of NIPA [1].
  • As the rise in temperature causes a decrease in the water content of the NIPA gel particles, the gel particles becomes stickier on the cavity wall of polystyrene PPM [2].
  • Phenotypic analysis revealed no selective increase in the number of CD3-CD8dim cells (thought to be a NK-like regulator cell) and the number of CD4+CD25+CD152+ cells (naturally occurring regulatory T cells) after stimulation with NIMA-expressing cells when compared with NIPA-expressing cells [3].

Biological context of ZC3HC1

  • We analyzed the in vitro T cell reactivity of healthy individuals toward their parents and/or siblings expressing the NIMA or NIPA haplotype to explore whether the alloimmune response to NIMA has distinct characteristics compared with NIPA [3].


  1. Identification and characterization of a nuclear interacting partner of anaplastic lymphoma kinase (NIPA). Ouyang, T., Bai, R.Y., Bassermann, F., von Klitzing, C., Klumpen, S., Miething, C., Morris, S.W., Peschel, C., Duyster, J. J. Biol. Chem. (2003) [Pubmed]
  2. Preparations and optical properties of ordered arrays of submicron gel particles: interconnected state and trapped state. Kumoda, M., Watanabe, M., Takeoka, Y. Langmuir : the ACS journal of surfaces and colloids. (2006) [Pubmed]
  3. No in vitro evidence for a decreased alloreactivity toward noninherited maternal HLA antigens in healthy individuals. van den Boogaardt, D.E., van Miert, P.P., Koekkoek, K.M., de Vaal, Y.J., van Rood, J.J., Claas, F.H., Roelen, D.L. Hum. Immunol. (2005) [Pubmed]
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