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Chemical Compound Review

CUMENE     propan-2-ylbenzene

Synonyms: Cumeen, Cumol, Cumenebottoms, AGN-PC-00LPBH, HSDB 172, ...
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Disease relevance of Latex


Psychiatry related information on Latex

  • These idiotopes were apparently more specific to individuals (private) as the anti-DPT antibodies of a given patient did not agglutinate latex particles coated with anti-Id antibodies prepared against Id of another patient [6].
  • We concluded that the latex test, Rubalex, was readily applicable for measuring rubella immunity with a reaction time of 2 min in undiluted samples [7].
  • For the latex balloons, the mean volume for pain threshold was 17 +/- 1.4 cc for S and 17 +/- 1.4 cc for R inflations on day 1 and 17 +/- 1.6 cc and 18 +/- 1.9 cc on day 2 [8].
  • METHODS: We used esophageal balloon distention to compare sensory thresholds between nine male and 10 female volunteers with a latex balloon (length 3 cm) positioned 5 cm proximal to the lower esophageal sphincter [9].
  • Locomotor activity dramatically decreased in mice dosed with PBCA NP, but not with PS NP [10].

High impact information on Latex


Chemical compound and disease context of Latex


Biological context of Latex


Anatomical context of Latex

  • Thrombin covalently linked to carboxylate-modified polystyrene beads initiated division of quiescent chick embryo (CE) cells either in medium containing low levels of serum or in serum-free medium [26].
  • Activation of the PNH neutrophils with IgG-coated latex beads appeared normal (although binding of dimer IgG complexes was reduced), indicating that FcRII, rather than FcRIII, is involved in neutrophil stimulation [27].
  • Hyperpolarisation of rat peritoneal macrophages phagocytosing latex particles [28].
  • Addition of latex beads or Schwann cell membranes does not induce channel clustering [29].
  • The importance of this problem is emphasized by reports that clearly non-physiological agents, such as positively charged latex beads, can cause AChR aggregation on cultured muscle cells [30].

Associations of Latex with other chemical compounds

  • The cholinergic agonist carbachol was conjugated to latex microspheres that were fluorescently labeled with rhodamine and used as neuroanatomical probes that show little diffusion from their injection site and retrogradely label neurons projecting to the injection site [31].
  • Resident, periodate-elicited, and BCG-activated mouse peritoneal macrophages were incubated with AcLDL, EIgG, EIgMC, dextran sulfate, latex, or zymosan, and the resulting protein secretion patterns were analyzed by [35S]methionine labeling and SDS-polyacrylamide gel electrophoresis [32].
  • In contrast, macrophage interactions with complement-coated (EAC) red cells, or ingestion of latex particles, yeast cell walls or glutaraldehyde-treated erythrocytes was not inhibited [33].
  • These results indicate that Fc- and C3 receptor-mediated phagocytosis (opsonin dependent) differs qualitatively from the ingestion of latex and zymosan particles (opsonin independent); they suggest that the same regulatory molecules govern the responses of phagocytic cells to signals initiated by both the Fc and C3 receptors [34].
  • Antibody binding to beta 2-GPI on the irradiated plates was competitively inhibited by simultaneous addition of cardiolipin (CL)-coated latex beads mixed together with beta 2-GPI but were unaffected by addition of excess beta 2-GPI, CL micelles, or CL-coated latex beads alone [35].

Gene context of Latex

  • However, absence of CCR2 led to an increased labeling of the minor Gr-1int monocyte population, and the number of latex+ DCs that emigrated to LNs was correspondingly increased [36].
  • With this assay we assessed the binding of TS in solution to proteins adsorbed to polystyrene microtiter plates [37].
  • The agonists of all TLRs expressed in neutrophils triggered or primed cytokine release, superoxide generation, and L-selectin shedding, while inhibiting chemotaxis to interleukin-8 (IL-8) and increasing phagocytosis of opsonized latex beads [38].
  • Latex beads coated with purified CD24 from the two carcinoma cell lines but also neutrophils could bind specifically to P-selectin-IgG [39].
  • Therefore, we evaluated whether cell-sized latex beads coated with HLA/mHag complexes HLA-A2/HA-1 or HLA-A2/HA-2 and recombinant CD80 and CD54 molecules can replace professional APCs [40].

Analytical, diagnostic and therapeutic context of Latex

  • Quick-freeze, deep-etch EM was used to analyze MTs polymerized from tubulin and cross-linked to latex microspheres by kinesin [41].
  • All of the women were provided with latex condoms and were instructed to have their male sexual partners use them [42].
  • Here we use video microscopy to demonstrate both the two-dimensional crystal-like ordering of charged nanometre-sized polystyrene spheres in water, and the enhanced spreading dynamics of a micellar fluid, at the three-phase contact region [43].
  • Bioassay of solubilized Bacillus thuringiensis var. israelensis crystals by attachment to latex beads [3].
  • Microfluidic networks (microFNs) were used to pattern biomolecules with high resolution on a variety of substrates (gold, glass, or polystyrene) [44].


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  10. Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity. Olivier, J.C., Fenart, L., Chauvet, R., Pariat, C., Cecchelli, R., Couet, W. Pharm. Res. (1999) [Pubmed]
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  17. Characterization of T cell responses to Hev b 3, an allergen associated with latex allergy in spina bifida patients. Bohle, B., Wagner, B., Vollmann, U., Buck, D., Niggemann, B., Szépfalusi, Z., Fischer, G., Scheiner, O., Breiteneder, H., Ebner, C. J. Immunol. (2000) [Pubmed]
  18. Chitin particle-induced cell-mediated immunity is inhibited by soluble mannan: mannose receptor-mediated phagocytosis initiates IL-12 production. Shibata, Y., Metzger, W.J., Myrvik, Q.N. J. Immunol. (1997) [Pubmed]
  19. Severe hyperkalemia during piroxicam therapy. Miller, K.P., Lazar, E.J., Fotino, S. Arch. Intern. Med. (1984) [Pubmed]
  20. Toxic oxygen metabolite production by circulating phagocytic cells in inflammatory bowel disease. Williams, J.G., Hughes, L.E., Hallett, M.B. Gut (1990) [Pubmed]
  21. Initiation of check cell division by trypsin action at the cell surface. Carney, D.H., Cunningham, D.D. Nature (1977) [Pubmed]
  22. Minus-end-directed motion of kinesin-coated microspheres driven by microtubule depolymerization. Lombillo, V.A., Stewart, R.J., McIntosh, J.R. Nature (1995) [Pubmed]
  23. Latex glove allergy. A survey of the US Army Dental Corps. Berky, Z.T., Luciano, W.J., James, W.D. JAMA (1992) [Pubmed]
  24. Response of bladder and urethral mucosa to catheterization. Anderson, R.U. JAMA (1979) [Pubmed]
  25. The spectrum of IgE-mediated responses to latex. Sussman, G.L., Tarlo, S., Dolovich, J. JAMA (1991) [Pubmed]
  26. Cell surface action of thrombin is sufficient to initiate division of chick cells. Carney, D.H., Cunningham, D.D. Cell (1978) [Pubmed]
  27. The PI-linked receptor FcRIII is released on stimulation of neutrophils. Huizinga, T.W., van der Schoot, C.E., Jost, C., Klaassen, R., Kleijer, M., von dem Borne, A.E., Roos, D., Tetteroo, P.A. Nature (1988) [Pubmed]
  28. Hyperpolarisation of rat peritoneal macrophages phagocytosing latex particles. Kouri, J., Noa, M., Diaz, B., Niubo, E. Nature (1980) [Pubmed]
  29. Clustering of voltage-dependent sodium channels on axons depends on Schwann cell contact. Joe, E.H., Angelides, K. Nature (1992) [Pubmed]
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  31. Mapping neuronal inputs to REM sleep induction sites with carbachol-fluorescent microspheres. Quattrochi, J.J., Mamelak, A.N., Madison, R.D., Macklis, J.D., Hobson, J.A. Science (1989) [Pubmed]
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  33. Selective phagocytic paralysis induced by immobilized immune complexes. Rabinovitch, M., Manejias, R.E., Nussenzweig, V. J. Exp. Med. (1975) [Pubmed]
  34. 2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated phagocytosis in mouse peritoneal macrophages II. Dissociation of the inhibitory effects of 2-deoxyglucose on phagocytosis and ATP generation. Michl, J., Ohlbaum, D.J., Silverstein, S.C. J. Exp. Med. (1976) [Pubmed]
  35. Anticardiolipin antibodies recognize beta 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. Matsuura, E., Igarashi, Y., Yasuda, T., Triplett, D.A., Koike, T. J. Exp. Med. (1994) [Pubmed]
  36. Role of CCR8 and other chemokine pathways in the migration of monocyte-derived dendritic cells to lymph nodes. Qu, C., Edwards, E.W., Tacke, F., Angeli, V., Llodrá, J., Sanchez-Schmitz, G., Garin, A., Haque, N.S., Peters, W., van Rooijen, N., Sanchez-Torres, C., Bromberg, J., Charo, I.F., Jung, S., Lira, S.A., Randolph, G.J. J. Exp. Med. (2004) [Pubmed]
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  40. Artificial antigen-presenting constructs efficiently stimulate minor histocompatibility antigen-specific cytotoxic T lymphocytes. Oosten, L.E., Blokland, E., van Halteren, A.G., Curtsinger, J., Mescher, M.F., Falkenburg, J.H., Mutis, T., Goulmy, E. Blood (2004) [Pubmed]
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