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Gene Review:

PHAX - phosphorylated adaptor for RNA export

Homo sapiens

Synonyms: FLJ13193, Phosphorylated adapter RNA export protein, RNA U small nuclear RNA export adapter protein, RNUXA

Ohno, M. et al., Boulon, S. et al.

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High impact information on RNUXA

In vivo, PHAX is required for U snRNA export but not for CRM1-mediated export in general [1].
PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation [1].
In agreement, PHAX does not export m7G-capped U3 precursors because their caps become hypermethylated in the nucleus [2].
Furthermore, PHAX also binds the precursors of U8 and U13 box C/D snoRNAs and telomerase RNA [2].

Biological context of RNUXA

The compartmentalized PHAX phosphorylation cycle can contribute to the directionality of export [1].

References

PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation. Ohno, M., Segref, A., Bachi, A., Wilm, M., Mattaj, I.W. Cell (2000) [Pubmed]
PHAX and CRM1 are required sequentially to transport U3 snoRNA to nucleoli. Boulon, S., Verheggen, C., Jady, B.E., Girard, C., Pescia, C., Paul, C., Ospina, J.K., Kiss, T., Matera, A.G., Bordonné, R., Bertrand, E. Mol. Cell (2004) [Pubmed]

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