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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

EEF1B2  -  eukaryotic translation elongation factor 1...

Bos taurus

 
 
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High impact information on EEF1B2

  • EF-1 beta strongly enhances the dissociation rate of the EF-1 alpha X GDP complex and to a lesser extent of the EF-1 alpha X GTP complex [1].
  • Therefore, unlike EF-1 beta, kirromycin cannot enhance the rate of poly(Phe) synthesis [1].
  • In the absence of aa-tRNA the rate-limiting step of the GTPase turnover appears to be the hydrolysis of GTP, whereas in its presence the GDP/GTP exchange reaction becomes rate-limiting, since addition of EF-1 beta enhances turnover GTPase activity [2].
  • Although in this regard the effect of kirromycin mimics that of EF-1 beta, the antibiotic is incapable of increasing the EF-1 alpha X GDP/GTP exchange rate when aa-tRNA and ribosomes are present [1].
 

Other interactions of EEF1B2

  • The relative molecular mass of the purified factors have been determined as: EF-1 alpha, 50,000; EF-1 beta, 30,000; the EF-1 gamma-like component, 49,000; EF-2, 85,000 [3].

References

  1. Characterization of the elongation factors from calf brain. 2. Functional properties of EF-1 alpha, the action of physiological ligands and kirromycin. Crechet, J.B., Parmeggiani, A. Eur. J. Biochem. (1986) [Pubmed]
  2. Characterization of the elongation factors from calf brain. 3. Properties of the GTPase activity of EF-1 alpha and mode of action of kirromycin. Crechet, J.B., Parmeggiani, A. Eur. J. Biochem. (1986) [Pubmed]
  3. Characterization of the elongation factors from calf brain. 1. Purification, molecular and immunological properties. Crechet, J.B., Canceill, D., Bocchini, V., Parmeggiani, A. Eur. J. Biochem. (1986) [Pubmed]
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